Imikhiqizo

(αS,3S) -α--[(tert-Butyloxycarbonyl) amino] -2-oxo-3-pyrrolidinepropanoic acid methyl ester, eyaziwa nangokuthi i-Boc-Amino acid methyl ester, iyinhlanganisela ebalulekile emkhakheni we-organic synthesis ne-peptide. chemistry.I-Boc-Amino acid methyl ester isebenza njengendlela evikelwe yama-amino acid, lapho iqembu le-Boc (tert-butyloxycarbonyl) lisetshenziselwa ukuvikela iqembu lama-amino phakathi nokusabela.Le nhlanganisela isetshenziswa ngokuyinhloko ekuhlanganiseni kwe-peptide ukwethula ama-amino acid athile emaketangeni e-peptide.Ama-Peptides amaketanga amafushane ama-amino acid adlala indima ebalulekile ezinhlelweni zezinto eziphilayo.Bahileleke ezinqubweni ezihlukahlukene ezifana nokusayina, ukulawulwa kwe-enzyme, nokusekelwa kwesakhiwo.I-Peptide synthesis ihlanganisa ukuhlanganiswa kwama-amino acid ngesinyathelo ngesinyathelo ukuze kudaleke ukulandelana okuqondile okulingisa ama-peptide emvelo noma ukudala izakhiwo zenoveli ezinezakhiwo ezifiselekayo.I-Boc-Amino acid methyl ester ivamise ukusetshenziswa njengebhlokhi yokwakha ku-solid-phase peptide synthesis (SPPS), okuyi enye yezindlela ezisetshenziswa kakhulu ukwakha ama-peptide.Ku-SPPS, iketango le-peptide lihlanganiswa ngendlela enesinyathelo ekusekelweni okuqinile, ngokuvamile kusetshenziswa okuphuma kokuphuma ku-amino acid neqembu elivikelayo lesikhashana.I-Boc-Amino acid methyl ester iyinto ekahle yokuqala ye-SPPS ngenxa yokuzinza, ukunyibilika, nokuhambisana namanye ama-reagents e-peptide synthesis.Ngesikhathi se-peptide synthesis, i-Boc-Amino acid methyl ester yengezwa ochungechungeni olukhulayo lwe-peptide ngokusebenzisa ukwakheka kwe-amide bond.Iqembu elivikelayo le-Boc livimbela ukusabela okungafuneki ohlangothini futhi liqinisekisa ukuhlangana okukhethiwe kwe-amino acid ochungechungeni lwe-peptide.Uma ukulandelana okufunayo sekufinyelelwe, iqembu le-Boc lisuswa ngaphansi kwezimo ezithambile, liveza iqembu lamahhala le-amino ukuze liphinde lilungiswe noma i-peptide characterization.Ngaphezu kwe-peptide synthesis, i-Boc-Amino acid methyl ester ingasetshenziswa futhi ekulungiseleleni imithi ehlukahlukene. i-intermediate, agrochemicals, nezinye izinhlanganisela eziphilayo.Ukusingathwa kwayo kalula, ukuzinza, nokuhambisana nezimo ezijwayelekile zokusabela kuyenza ibe ibhulokhi yokwakha eguquguqukayo ye-organic synthesis.Sekukonke, i-Boc-Amino acid methyl ester iyithuluzi elibalulekile ekuhlanganiseni kwe-peptide kanye ne-organic chemistry.Indima yayo njengendlela evikelekile yama-amino acid ivumela ukuhlanganiswa okuphumelelayo kwamaketanga e-peptide nokudala izakhiwo ze-peptide ezihlukahlukene zocwaningo, ukutholakala kwezidakamizwa, kanye nezicelo zokwelapha.