1-(3-Carboxypyrid-2-yl)-2-phenyl-4-methyl-piperazine CAS: 61338-13-4
| Inombolo Yekhathalogi | XD93391 |
| Igama Lomkhiqizo | 1-(3-Carboxypyrid-2-yl)-2-phenyl-4-methyl-piperazine |
| I-CAS | 61338-13-4 |
| Ifomu le-Molecularla | I-C17H19N3O2 |
| Isisindo samangqamuzana | 297.35 |
| Imininingwane Yesitoreji | I-ambient |
Ukucaciswa Komkhiqizo
| Ukubukeka | Impushana emhlophe |
| U-Asay | 99% iminithi |
I-1-(3-Carboxypyrid-2-yl)-2-phenyl-4-methyl-piperazine, eyaziwa nangokuthi i-CPPMP, iyinhlanganisela yamakhemikhali enesakhiwo esiyinkimbinkimbi esinezinto ezihlukahlukene ezingase zisetshenziswe emkhakheni wamakhemikhali emithi.Okunye okungase kube ukusetshenziswa ye-CPPMP isekwelapheni ukuphazamiseka kwemizwa.Ukuba khona kweqembu le-carboxypyridyl kubonisa amandla alo okuxhumana nama-neuronal receptors athile ohlelweni lwezinzwa olumaphakathi.Ukuqondisa lawa ma-receptors kungashintsha ukuhanjiswa kwe-neurotransmission, okungase kuholele emiphumeleni yokwelapha ezimeni ezinjengokucindezeleka, ukukhathazeka, noma ukuphazamiseka kwe-neurodegenerative.Ucwaningo olwengeziwe luyadingeka ukuze kuhlolwe ukusebenzisana kwe-receptor ethile kanye nendlela yokusebenza ye-CPPMP ukuze kuthuthukiswe amandla ayo njenge-ejenti yokwelapha yezinkinga ze-neurological.Isakhiwo esiyinhloko se-piperazine ye-CPPMP futhi sibonisa amandla ayo njengenhlanganisela eholayo yokuthuthukiswa kwemithi emisha.Osokhemisi bezokwelapha bangashintsha izingxenye ezihlukene zesakhiwo sayo ukuze bathuthukise izakhiwo zayo zemithi noma baqondise izindlela ezithile zebhayoloji.Ngokuthuthukisa isakhiwo se-CPPMP, abacwaningi bangakwazi ukuklama okuphumayo ngokukhetha okuthuthukisiwe, amandla, kanye namaphrofayili okuphepha, okubenza bafanelekele izidakamizwa eziqondiswe ezifweni ezihlukahlukene.Ngaphezu kwalokho, amaqembu e-CPPMP's phenyl kanye ne-methyl ahlinzeka ngezakhiwo ze-hydrophobic, ezingase zibe nenzuzo ekuthuthukiseni izidakamizwa ezingawela. ulwelwesi lwamaseli nokufinyelela okuhlosiwe kwe-intracellular.Lesi sici singasetshenziselwa ukuklama izidakamizwa zenoveli eziqondise ngokuqondile ama-enzyme noma izindlela ze-intracellular, ezihlinzeka ngamathuba okungenelela kwezokwelapha ezifweni ezifana nomdlavuza noma ukuphazamiseka kwe-metabolic.Ukwengeza, izici eziyingqayizivele zesakhiwo se-CPPMP zivumela ukuthuthukiswa okungenzeka kwezidakamizwa noma izinhlelo zokulethwa kwezidakamizwa. .Ngokulungisa iqembu layo le-carboxypyridyl, inhlanganisela ingaklanywa ukuthi izinze noma ibe nobuthi obuncane ngendlela yayo yomdabu, kuyilapho iletha ngempumelelo i-moiety yesidakamizwa esisebenzayo endaweni oyifunayo.Ukuguqulwa okunjalo kungathuthukisa i-bioavailability kanye nempumelelo yokwelapha ye-compound.Kufanele kuqashelwe ukuthi ukusetshenziswa kwe-CPPMP kulezi zicelo ezingase zibe khona kuwukuqagela futhi kuzodinga ucwaningo olubalulekile nokuthuthukiswa ngaphambi kokusetshenziswa okungokoqobo.Ngaphezu kwalokho, konke ukusetshenziswa kwe-CPPMP kuzodingeka ukuthi kulandele izimiso zokuphepha ezimisiwe neziqondiso ukuze kuqinisekiswe ukuphathwa ngendlela efanele nokunciphisa ubungozi. , inesithembiso sezinhlelo zokusebenza ezahlukahlukene kukhemikhali yezokwelapha.Ukwakheka kwayo okuyinkimbinkimbi kuveza amathuba okuthuthukiswa kwama-ejenti anoveli okwelapha ezinkingeni zemizwa, kanye nezidakamizwa eziqondise ezifweni ezahlukene.Ngokucwaninga okwengeziwe nokwenza kahle, i-CPPMP inamandla okwenza iminikelo ebalulekile emkhakheni wezokwelapha futhi ithuthukise imiphumela yesiguli.
