Imikhiqizo

I-1-(3-Hydroxymethylpyridin-2-yl)-4-methyl-2-phenylpiperazine iyinhlanganisela yekhemikhali enezinhlobonhlobo ezingaba zibanzi zokusetshenziswa kukhemikhali yezokwelapha kanye nokuthuthukiswa kwezidakamizwa.Okunye okungase kube khona ukusetshenziswa kwalesi sakhi kumkhakha wekhemikhali yezokwelapha. , ikakhulukazi ekutholakaleni kwezidakamizwa.Ukuba khona kweqembu le-hydroxymethylpyridinyl kuphakamisa ukusebenzisana okungaba khona nezinhloso ezithile zebhayoloji, njengama-enzyme noma ama-receptors.Osokhemisi bezokwelapha bangakwazi ukuthuthukisa ukwakheka kwale nhlanganisela ukuze kuthuthukiswe ukuhlobana kwayo okubophezelayo kanye nokukhetha ekuqondisweni okuhlosiwe kwebhayoloji.Ngokushintsha i-phenyl ne-piperazine moieties, abacwaningi bangakwazi ukulungisa izakhiwo ze-physicochemical ze-compound kanye ne-pharmacokinetics, okungaholela ekusebenzeni okuthuthukisiwe kwezidakamizwa kanye nokunciphisa imiphumela emibi engadingeki.Okunye ukusetshenziswa okungenzeka kwe-1-(3-Hydroxymethylpyridin-2-yl) -4 -methyl-2-phenylpiperazine ilele emkhakheni we-neuropharmacology.Isakhiwo sale nhlanganisela siphakamisa ukusebenzisana okungenzeka nama-receptors ohlelweni lwezinzwa olumaphakathi, okungase kuholele emiphumeleni yokwelapha ezinkingeni zemizwa.Isibonelo, ingacutshungulwa njengekhandidethi lokulungisa ukuhanjiswa kwe-neurotransmission ezimeni ezifana nokukhathazeka, ukudangala, noma i-schizophrenia.Abacwaningi bangase baphenye indlela yokusebenza kwenhlanganisela futhi benze izifundo zangaphambi komtholampilo kanye nezomtholampilo ukuze bahlole amandla ayo okwelapha.Ngaphezu kwalokho, izici zesakhiwo sale nhlanganisela zingayenza ifanelekele izicelo zokulethwa kwezidakamizwa.Amaqembu ayo e-hydrophobic phenyl kanye namaqembu e-methyl aphakamisa amandla okuwela ulwelwesi lwe-lipid, okulwenza luqondise ama-enzyme noma izindlela ze-intracellular.Lesi sakhiwo sinenzuzo ekwenzeni izidakamizwa ezidinga ukungena kumaseli futhi zenze imiphumela yazo kokuhlosiwe okuqondile kwe-intracellular.Ngokushintsha ukwakheka kwe-compound, osokhemisi bezokwelapha bangathuthukisa i-bioavailability yayo, bathuthukise ukuzinza, futhi bathuthukise amasu asebenzayo okulethwa kwezidakamizwa.Kubalulekile ukuqaphela ukuthi ukusetshenziswa kwe-1-(3-Hydroxymethylpyridin-2-yl) -4-methyl-2 -phenylpiperazine kulezi zicelo ezingase zibe khona kudinga ukuhlolwa okuqinile kwe-preclinical kanye nokwelashwa ukuze kuqinisekiswe ukuphepha, ukusebenza kahle, kanye nesilinganiso esifanele.Ucwaningo olunzulu lwesayensi yemithi kanye ne-toxicological luyadingeka ukuze kuqondwe imiphumela yako ezinhlelweni ezahlukene zebhayoloji kanye nokuthola noma yimiphi imiphumela emibi engaba khona. izicelo ezingaba khona kukhemikhali yezokwelapha kanye nokuthuthukiswa kwezidakamizwa.Inesithembiso sokuklanywa kwemithi emisha, ikakhulukazi ezindaweni ze-neuropharmacology kanye nokulethwa kwezidakamizwa.Ucwaningo olwengeziwe luyadingeka ukuze kuhlolwe ukuxhumana kwayo okuqondile, indlela yokusebenza, namandla okwelapha, okuvula indlela yempumelelo engaba khona ekwelapheni izifo nokuphazamiseka okuhlukahlukene.