Imikhiqizo

I-1-(4-Methoxyphenyl) piperazine dihydrochloride, eyaziwa nangokuthi i-4-MeO-PP, iyinhlanganisela yamakhemikhali enohlu lwezinhlelo zokusebenza emikhakheni yezemithi nocwaningo.Isetshenziswa kabanzi njengendawo emaphakathi noma eyandulelayo ekuhlanganisweni kwezidakamizwa ezimbalwa nanjengenhlanganisela yethuluzi lokufunda izinqubo ezahlukahlukene zebhayoloji. ama-ejenti okwelapha.Isakhiwo sayo samangqamuzana esiyingqayizivele sivumela ukuguqulwa nokusebenza, okuvumela ukuhlanganiswa kwamakhandidethi emishanguzo emisha ngomsebenzi wokwelapha ongaba khona.Ukuba khona kweqembu le-piperazine esakhiweni salo kwenza kube yigugu ngokukhethekile ekudalweni kwemithi eqondisa isimiso sezinzwa esiyinhloko, njenge-antipsychotics, antidepressants, kanye ne-anxiolytics.1-(4-Methoxyphenyl) piperazine dihydrochloride nayo idlala indima ebalulekile ocwaningweni. kanye nemisebenzi yokuthuthukisa ehlobene ne-neuroscience ne-pharmacology.Ngokuvamile isetshenziswa njengenhlanganisela yethuluzi lokuphenya ukubopha kwama-receptor, izinqubo ze-neurochemical, nokusebenzisana kwezidakamizwa.Abacwaningi basebenzisa le nhlanganisela ukuze bafunde imiphumela yezidakamizwa ezihlukahlukene ezinhlelweni ze-neurotransmitter, ama-receptor subtypes, nezindlela zokudlulisa isignali.Ngokuqonda lezi zindlela, ososayensi bangathola ukuqonda ngezifo eziyinkimbinkimbi njenge-schizophrenia, ukuphazamiseka kokukhathazeka, nokucindezeleka, okuholela ekuthuthukisweni kwezindlela zokwelapha ezinoveli.Ngaphezu kwalokho, i-1-(4-Methoxyphenyl) i-piperazine dihydrochloride isetshenziswa ekuthuthukiseni ama-radioligands e-positron. I-emission tomography (PET), inqubo esetshenziselwa ukubona ngeso lengqondo kanye nokulinganisa izinqubo ezithile ze-biochemical emzimbeni womuntu.Ngokuhlanganisa ama-isotopes anemisebe esakhiweni senhlanganisela, ososayensi bangakha ama-radiotracer abopha kuma-receptors athile ebuchosheni.Lokhu kuvumela ukucabangela okungahlanyisi nokuhlaziywa komthamo we-receptor density, ukusatshalaliswa, kanye nokuhlala, kusiza ekuqondeni ukuphazamiseka okuhlukahlukene kwemizwa.Kubalulekile ukusebenzisa ukuqapha okufanele lapho uphatha i-1-(4-Methoxyphenyl)piperazine dihydrochloride, njengoba into engaba yingozi.Izimiso zokuphepha kanye nempahla yomuntu siqu yokuzivikela kufanele kusetshenziswe ukunciphisa ubungozi bokuchayeka ngephutha enkomponi. Ukufingqa, i-1-(4-Methoxyphenyl)piperazine dihydrochloride iyinhlanganisela eguquguqukayo esetshenziswa embonini yezemithi neyocwaningo.Indima yayo njengendawo emaphakathi ekuhlanganiseni izidakamizwa kanye nenhlanganisela yethuluzi lokufunda izinqubo zebhayoloji iyenza ibe wusizo ezinhlelweni ezihlukahlukene zokusebenza, kusukela ekuthuthukisweni kwemithi emisha kuya ekuphenyweni kwezinhlelo eziyinkimbinkimbi ze-neurochemical.Izinyathelo zokuphepha kufanele zihlale zibhekwa ngesikhathi sokuphatha.