Imikhiqizo

I-1-Methyl-4-pyrazole boronic acid pinacol ester iyinhlanganisela yamakhemikhali edlala indima ebalulekile emkhakheni we-organic chemistry nokutholwa kwezidakamizwa.Ine-boronic acid moiety, okuyenza ibe yisakhiwo esibalulekile sokwenza ama-molecule ahlukahlukene ezinto eziphilayo.Okunye okuyisisekelo kwe-1-Methyl-4-pyrazole boronic acid pinacol ester kusemkhakha wamakhemikhali okwelapha.Ivame ukusetshenziswa njengesandulela noma esimaphakathi ekuhlanganiseni kwezinhlanganisela zemithi.Ama-boronic acids aziwa ngokukwazi kwawo ukwenza ama-complexes azinzile nama-enzyme athile, ikakhulukazi ama-protease.Lesi sakhiwo sibenza babe amathuluzi afanelekile okuthuthukisa ama-enzyme inhibitors angakhomba izifo ezithile.Ngokuhlanganisa i-pyrazole moiety ku-boronic acid, inhlanganisela ewumphumela ibonisa ukuhambisana okubophezelayo okuthuthukisiwe kanye nokukhetha ku-enzyme eqondiwe.Lokhu kwenza i-1-Methyl-4-pyrazole boronic acid pinacol ester ibe yisakhiwo esibalulekile semizamo yokuthola izidakamizwa eziqondiswe kwizifo ezisekelwe ku-protease njengomdlavuza, ukuvuvukala, kanye nezifo ezibangelwa amagciwane. Ngaphezu kwalokho, i-boronic acid ku-1-Methyl-4-pyrazole boronic acid. I-pinacol ester ingabhekana nokusabela okuhlukahlukene kwamakhemikhali, njengokusabela kwe-Suzuki-Miyaura cross-coupling kanye nokusabela kwe-Heck.Lokhu kusabela kuvumela ukwakheka kwamabhondi e-carbon-carbon, okwenza kube lula ukuhlanganiswa kwezakhiwo eziyinkimbinkimbi eziphilayo.Iqembu le-pyrazole lengeza okunye ukuhlukahluka kanye nokusebenza kwezinhlanganisela ezihlanganisiwe, okwenza i-1-Methyl-4-pyrazole boronic acid pinacol ester i-reagent eguquguqukayo ku-organic synthesis.Ngaphezu kwalokho, i-1-Methyl-4-pyrazole boronic acid pinacol ester ibonise amandla ukuthuthukiswa kwezinto ezisekelwe ku-boron.Iqembu le-boronic acid linezakhiwo eziyingqayizivele ezivumela ukuthi libambe iqhaza ezinqubweni zokuzihlanganisa, okuholela ekwakhiweni kwezakhiwo ze-supramolecular.Leli khono liye lahlolwa emkhakheni wesayensi yezinto zokwakha ukudala izinto ezisebenzayo, ezifana nama-gel, amafilimu, nama-nanoparticles, angathola izinhlelo zokusebenza ku-electronics, catalysis, kanye nokulethwa kwezidakamizwa.Ngokufingqa, i-1-Methyl-4-pyrazole boronic acid I-pinacol ester iyinhlanganisela eguquguqukayo enezinhlobonhlobo zezicelo.Ukusebenza kwayo kwe-boronic acid kuvumela ukuhlanganiswa kwama-molecule ezinto eziphilayo eziyinkimbinkimbi, okwenza kube isisekelo sokwakha esibalulekile ekutholakaleni kwezidakamizwa kanye nokuhlanganiswa kwezinto eziphilayo.Ukwengeza, izakhiwo zayo eziyingqayizivele zivumela ukwakheka kwezinto ze-supramolecular ezingasetshenziswa emikhakheni ehlukahlukene.Sekukonke, imvelo yayo enezici eziningi yenza i-1-Methyl-4-pyrazole boronic acid pinacol ester ibe ithuluzi elibalulekile labacwaningi emikhakheni eyahlukene yesayensi.