Imikhiqizo

I-1-Methyl-4-pyrazole boronic acid pinacol ester iyinhlanganisela enezinhlobonhlobo zezinhlelo zokusebenza, ikakhulukazi emkhakheni we-organic synthesis.Isakhiwo sayo esiyingqayizivele kanye nokusebenza kabusha kwe-reactivity kuyenza ibe yigugu ekuphenduleni kwamakhemikhali okuhlukahlukene futhi njengebhlokhi yokwakha ukuhlanganiswa kwama-molecule ayinkimbinkimbi.Okunye ukusetshenziswa okubalulekile kwe-1-Methyl-4-pyrazole boronic acid pinacol ester kukwakhiwa kwe-carbon-carbon noma amabhondi e-carbon-heteroatom.Iqembu le-boronic acid ku-molecule lingakwazi ukubhekana nokuhlangana kwe-Suzuki-Miyaura, okuvumela ukunamathiselwa kwe-1-methyl-4-pyrazole moiety kwezinye izinhlanganisela noma amaqembu asebenzayo.Lokhu kusabela kuvumela osokhemisi ukuthi benze izinhlanganisela eziphilayo eziyinkimbinkimbi ezinezakhiwo ezihambisanayo kanye nezakhiwo.Ukwengeza, iqembu le-pinacol ester ku-molecule linikeza ukuzinza futhi livikela ukusebenza kwe-boronic acid ngesikhathi sokusabela okuhlukahlukene.Leli qembu elivikelayo lingasuswa kalula ngaphansi kwezimo ezithambile, ngaleyo ndlela lidalule iqembu le-boronic acid ukuze kube noshintsho oluqhubekayo.Ngenxa yalokho, i-1-Methyl-4-pyrazole boronic acid pinacol ester isebenza njengendawo eguquguqukayo emaphakathi ekuhlanganiseni kwemithi, amakhemikhali ezolimo, namanye amakhemikhali amahle. abafuna izidakamizwa.Ngokusebenzisa i-1-Methyl-4-pyrazole boronic acid pinacol ester njengento yokuqala, osokhemisi bangakwazi ukwethula i-1-methyl-4-pyrazole moiety ibe yi-molecule eqondiwe, banikeze izici ezithile noma ukusebenza.Izinhlanganisela eziwumphumela zingabonisa umsebenzi webhayoloji othuthukisiwe, i-pharmacokinetics ethuthukisiwe, noma ubuthi obuncishisiwe.Ngaphezu kwalokho, i-1-Methyl-4-pyrazole boronic acid pinacol ester ibalulekile kusayensi yezinto ezibonakalayo kanye ne-catalysis.Ingasebenza njenge-ligand, ixhumane nama-catalysts ensimbi futhi ibambe iqhaza ekuphenduleni okuhlukahlukene kwe-catalytic.Iqembu le-boronic acid yaleli qembu lingakha ama-complexes anezinsimbi eziguqukayo, okuvumela ukuthi kusebenze amabhondi e-CH noma i-catalysis of cross-coupling reactions.Lezi zakhiwo zikwenza kube usizo ekuhlanganisweni kwezinto ezisebenzayo noma ukuthuthukiswa kwezinhlelo ezintsha ze-catalytic.Kafushane, i-1-Methyl-4-pyrazole boronic acid pinacol ester iyinhlanganisela eguquguqukayo enezinhlelo zokusebenza ezibalulekile ku-organic synthesis, imithi, isayensi yezinto ezibonakalayo, kanye i-catalysis.Ukusebenza kwayo kwe-boronic acid kanye neqembu le-pinacol ester kuyenza isebenziseke ekuphenduleni kokwakheka kwebhondi ye-carbon-carbon noma i-carbon-heteroatom, okuvumela ukwakhiwa kwama-molecule ayinkimbinkimbi.Isebenza ezimbonini ezahlukahlukene, okuhlanganisa ukuhlanganiswa kwemithi, ukuthuthukiswa kwezinto ezisebenzayo, kanye nokuthuthukiswa kwezinhlelo ze-catalytic.Ukuguquguquka nokusebenza kabusha kwe-1-Methyl-4-pyrazole boronic acid pinacol ester kuyenza ithuluzi elibalulekile losokhemisi abasebenza ekuhlanganiseni izinhlanganisela zenoveli kanye nokwakhiwa kwezisombululo ezintsha.