Imikhiqizo

(1R,2S,5S)—6,6-DiMethyl-3-aza-bicylo[3.1.0]hexane-2-carboxylic acid I-Methyl ester hydrochloride iyinhlanganisela yamakhemikhali enezinhlelo zokusebenza ezihlukahlukene ocwaningweni lwezemithi nasekuthuthukisweni kwezidakamizwa. ukusetshenziswa okubalulekile kwalesi sithako kufana nesakhiwo se-chiral ekuhlanganisweni kwemithi ephakathi kwemithi kanye nezithako ezisebenzayo zemithi (ama-API).Isakhiwo sayo se-bicyclic esiyingqayizivele kanye nobumnene kuyenza ibaluleke ekukhiqizeni izinhlanganisela ezihlanzekile ze-enantiomerically.Ngokuhlanganisa le nhlanganisela ku-synthesis, osokhemisi bangakwazi ukulawula i-stereochemistry futhi benze izici ezithile zemithi kuma-molecule avelayo.Lokhu kubaluleke kakhulu ekuthuthukisweni kwezidakamizwa, lapho umsebenzi webhayoloji oyifunayo ngokuvamile uncike ekuhlelweni kwendawo kwe-molecule.Ukwengeza, (1R,2S,5S)—6,6-DiMethyl-3-aza-bicylo[3.1.0]hexane -2-carboxylic acid I-Methyl ester hydrochloride isetshenziswa njengesandulela sokuhlanganiswa kwezidakamizwa ezisekelwe ku-quinuclidine.Okuphuma ku-Quinuclidine kubonise inhlobonhlobo yemisebenzi yebhayoloji, okuhlanganisa i-antipsychotic, i-anticonvulsant, ne-analgesic properties.Ngokwethula amaqembu athile asebenzayo ku-compound, osokhemisi bangakwazi ukuguqula izakhiwo zayo ze-pharmacokinetic kanye ne-pharmacodynamic, bathuthukise amandla ayo okwelapha.Ngaphezu kwalokho, le nhlanganisela ithola ukusetshenziswa njenge-reactant noma i-catalyst ekuguqulweni kwezinto eziphilayo.Ngenxa yobukhona be-amine ephakeme kanye nemvelo evimbelwe ngokuqinile yamaqembu e-methyl, ingabamba iqhaza ekuphenduleni kwamakhemikhali okuhlukahlukene, njengokusabela kwe-amidation, alkylation, kanye ne-cycloaddition.Ukusebenza kabusha kwayo kanye nekhono lokwakha izixhumanisi eziyinkimbinkimbi kuyenza ibe ithuluzi eliguquguqukayo ku-organic synthesis, okuvumela ukwakhiwa kwezinhlanganisela ezihlukene ngokwesakhiwo. .0]i-hexane-2-carboxylic acid I-Methyl ester hydrochloride iyinhlanganisela ebalulekile ekuthuthukisweni kwezidakamizwa kanye nokuhlanganiswa kwezinto eziphilayo.Ubuhle bayo kanye nesakhiwo esiyingqayizivele kuvumela ukukhiqizwa kwezinhlanganisela ezihlanzekile ze-enantiomerically kanye nokuhlanganiswa kwezidakamizwa ezisekelwe ku-quinuclidine ezinezakhiwo ezithile zemithi.Ukusebenza kabusha kwayo kuphinde kuyenze i-reactant ewusizo kanye ne-catalyst ekuguqulweni kwamakhemikhali okuhlukahlukene.Sekukonke, lesi sithako sidlala indima enkulu ekuthuthukisweni kocwaningo lwezemithi kanye nokwakhiwa kwama-ejenti amasha okwelapha.