Imikhiqizo

I-compound 2-({(5S)-2-oxo-3-[4-(3-oxomorpholin-4-yl)phenyl]-1,3-oxazolidin-5-yl}methyl)-1H-isoindole-1, I-3(2H)-dione i-molecule eyinkimbinkimbi ephilayo engase isetshenziswe emkhakheni wezokwelapha kanye nemithi.Ukuba khona kwe-isoindole core kubonisa ukuthi le nhlanganisela inezici zesakhiwo ezihambisana ne-biologically futhi zitholwe kuma-molecule e-bioactive.I-Isoindole derivatives iye yabikwa ukuthi inezinto ezihlukahlukene ze-pharmacological, kuhlanganise ne-antitumor, anti-inflammatory, kanye nemisebenzi ye-antimicrobial.I-oxazolidinone moiety, emele iqembu le-1,3-oxazolidin-5-yl, iyaziwa ngomsebenzi wayo wokulwa namagciwane.I-Oxazolidinone isetshenziswe njengezithako ezibalulekile kuma-antibiotics, ikakhulukazi ngokumelene namagciwane amelana nemithi.Lokhu kusikisela ukuthi inhlanganisela ingase ibe namandla njenge-ejenti elwa namagciwane.Ukuba khona kwe-morpholinone moiety, emelwe yiqembu le-phenyl engu-4-(3-oxomorpholin-4-yl), kwengeza ubunkimbinkimbi obengeziwe ekusetshenzisweni okungase kube khona kwenhlanganisela.Ama-morpholine afakwe kabanzi ezinhlanganisela zokwelapha ngenxa yekhono lawo lokusebenzelana nezinto ezihlosiwe zebhayoloji ezihlukahlukene.Iqembu le-oxo ku-morpholinone lingase lithuthukise ukusebenzisana kwenhlanganisela ngokuhlosiwe okuqondile, okulenze libe yisakhiwo esibalulekile ekutholweni kwezidakamizwa nasekuthuthukisweni.I-2-oxo-3-[4-(3-oxomorpholin-4-yl)phenyl]- Iqembu le-1,3-oxazolidin-5-yl, elihlanganiswe ne-isoindole core, lakha indawo eyinhloko esebenzayo ye-compound.Isakhiwo samakhemikhali esikhethekile saleli qembu siphakamisa ukuthi lingase libe nokusebenzisana nezinto ezihlosiwe zebhayoloji njengama-enzyme noma ama-receptors.Sekukonke, ngokusekelwe ezicini zesakhiwo senhlanganisela, linamandla okubonisa imisebenzi yezokwelapha ku-antibacterial, anti-inflammatory, kanye nezinye izindawo ezingaba zokwelapha.Kodwa-ke, ukusetshenziswa kwayo okuqondile nezindlela zokwenza kuyodingeka kunqunywe ngocwaningo olwengeziwe, okuhlanganisa ukuhlolwa kwe-in vitro kanye ne-vivo, ukuze kuhlolwe ukusebenza kwayo kanye namaphrofayili okuphepha. Ekugcineni, inhlanganisela 2-({(5S)-2-oxo -3-[4-(3-oxomorpholin-4-yl)phenyl]-1,3-oxazolidin-5-yl}methyl)-1H-isoindole-1,3(2H)-dione ibonisa isithembiso emkhakheni wezokwelapha kanye nemithi ngenxa yesakhiwo sayo esiyinkimbinkimbi kanye nezakhiwo zemithi ezingase zibe khona.Ucwaningo lwesikhathi esizayo luyadingeka ukuze kuhlolwe ukusetshenziswa kwalo okuqondile, izindlela zokwelapha ezingase zibe khona, kanye nokusebenza ngempumelelo kwayo yonke.