Imikhiqizo

I-2-Pyrrolidinecarboxamide, 1-(2-chloroacetyl)-, (2S)- iyinhlanganisela enezinhlelo zokusebenza ezihlukahlukene emkhakheni we-organic chemistry kanye nocwaningo lwezemithi.Le nhlanganisela, eyaziwa nangokuthi (2S) -2-Pyrrolidinecarboxamido-2-chloroacetic acid amide, ibonisa izici zesakhiwo ezenza ifaneleke ukusabela okuthile kwamakhemikhali nezifundo zebhayoloji.In organic synthesis, (2S) -2-Pyrrolidinecarboxamido-2-chloroacetic i-asidi amide ingasetshenziswa njengento yokuqala noma emaphakathi ekuhlanganiseni ama-molecule ayinkimbinkimbi.Imvelo yayo ye-chiral, enegama (2S), isikisela ukuthi inohlelo oluthile lwe-athomu enezinhlangothi ezintathu ezingaba nomthelela kumakhemikhali asetshenziswayo kanye nezakhiwo zokuphuma kokunye okuphuma kuyo.Le ndawo iyenza ibe yigugu ekwakhiweni nasekukhiqizweni kwemithi emisha kanye nezinhlanganisela zemithi.Embonini yezemithi, (2S) -2-Pyrrolidinecarboxamido-2-chloroacetic acid amide iye yacutshungulwa ngamandla ayo njengesivimbeli sama-enzyme noma amaprotheni ahilelekile. izinqubo ezithile zebhayoloji.Olunye ucwaningo lugxile ekusetshenzisweni kwalo njengesivimbeli sama-protease athile, okungama-enzyme adlala indima ezinqubweni ezihlukahlukene zomzimba.Ngokuqondisa ngokukhetha kanye nokuvimbela lawa ma-protease, imiphumela ehambisana nokwelashwa ingafinyelelwa.Ukwengeza, (2S) -2-Pyrrolidinecarboxamido-2-chloroacetic acid amide ingase isebenze njengesandulela sokuhlanganiswa kwe-peptide analogs noma i-mimetics.Lawa ma-molecule angakwazi ukulingisa ukwakheka nokusebenza kwama-peptide enzeka ngokwemvelo, ngaleyo ndlela abe nomthelela ekuhlosweni okuthile kwebhayoloji noma imisebenzi.Ama-analogue anjalo angaba nezinhlelo zokusebenza ezingaba khona ekuthuthukisweni kwezidakamizwa zokwelashwa kwezifo ezahlukahlukene, okubandakanya umdlavuza, ukuphazamiseka kwe-metabolic, nezimo zemizwa.Kubalulekile ukuqaphela ukuthi (2S) -2-Pyrrolidinecarboxamido-2-chloroacetic acid amide isetshenziswa kakhulu ocwaningweni lwaselabhorethri futhi ayivunyelwe ukusetshenziswa emtholampilo.Izindlela zokwelapha ezingase zibe khona zisacutshungulwa, futhi ucwaningo olwengeziwe luyadingeka ukuze kutholwe ukuphepha nokusebenza kahle kwayo kubantu.Ekuphetheni, i-(2S) -2-Pyrrolidinecarboxamido-2-chloroacetic acid amide iyinhlanganisela enezinhlelo zokusebenza ezahlukahlukene ku-organic synthesis futhi ucwaningo lwezemithi.Ubunjalo bayo be-chiral namandla okuvimbela ama-enzyme athile noma amaprotheni kuyenza ibe wusizo ekuthuthukisweni kwemithi emisha namasu okwelapha.Nakuba ukusetshenziswa kwayo ocwaningweni lwaselabhorethri kukhombisa isithembiso, uphenyo olwengeziwe luyadingeka ukuze uqonde ngokugcwele amandla ayo ezicelweni zomtholampilo.