Imikhiqizo

I-2,2,2-Trifluoroethanol iwutshwala obuyi-fluorinated oluthola ukusetshenziswa okuningana okubalulekile emikhakheni ehlukahlukene, okuhlanganisa nemithi, amakhemikhali ezolimo, kanye nesayensi yezinto.Izakhiwo zayo zamakhemikhali eziyingqayizivele ziyenza ibe yisakhiwo esibalulekile kanye ne-reagent ku-synthesis.Ukusetshenziswa okukhulu kwe-2,2,2-trifluoroethanol kufana ne-solvent kanye ne-co-solvent.Inamandla okuncibilikisa inhlanganisela ebanzi yezinto eziphilayo kanye ne-inorganic ngenxa ye-polarity eqinile namandla okunikela ngebhondi ye-hydrogen.Lokhu kuyenza isebenziseke ikakhulukazi ezinqubweni ezidinga ukuncibilikisa ama-substrates ayinselele, njenge-polar ne-nonpolar solutes, usawoti wensimbi, noma ama-polymers.Ngokuvamile isetshenziswa ocwaningweni lwezemithi nasekuthuthukisweni njenge-solvent ye-peptide synthesis futhi njenge-co-solvent ukuze kuthuthukiswe ukunyibilika kwezidakamizwa ezingancibiliki kahle.2,2,2-Trifluoroethanol iphinde isetshenziswe njenge-reagent eguquguqukayo yokuguqulwa kwamakhemikhali okuhlukahlukene.Ingangena esikhundleni se-nucleophilic, i-acylation, kanye nokusabela kwe-condensation ngenxa yokuba khona kokubili kweqembu eliqinile le-electron-withdrawing trifluoromethyl kanye neqembu elisebenzayo le-hydroxy.Lokhu kusabela kungabangelwa ukuba khona kwezisekelo eziqinile noma ama-asidi.Kubaluleke kakhulu ekuphenduleni okudinga ukwethulwa noma ukuguqulwa kwama-substituents e-trifluoromethyl, njengoba isebenza njengomthombo weqembu le-trifluoromethyl.Ku-organic synthesis, i-2,2,2-trifluoroethanol ivame ukusetshenziselwa ukuhlanganiswa kwezinhlanganisela ze-fluorinated.Ingasebenza njengesandulela sokudala amabhlogo wokwakha e-trifluoromethylated noma ane-fluorinated, abalulekile ekuthuthukisweni kwemithi namakhemikhali ezolimo.Iqembu le-trifluoromethyl lingathuthukisa i-bioactivity kanye nokuzinza kwe-metabolic kwama-molecule ezidakamizwa, okwenza kube okuhlosiwe okukhangayo kwamakhemikhali emithi.Ngaphezu kwalokho, i-2,2,2-trifluoroethanol isetshenziswa njenge-ejenti yokuxazulula i-chiral ngenxa yekhono layo lokwakha i-hydrogen bonding complexes ezinzile nge-chiral. izinhlanganisela.Lesi sakhiwo sivumela ukuhlukaniswa kwama-enantiomers, okungama-isomer esithombe sesibuko se-molecule, futhi kubalulekile ekukhiqizeni izithako zemithi ezihlanzekile. Nakuba i-2,2,2-trifluoroethanol inikeza izinzuzo eziningi ezinhlelweni ezihlukahlukene, kubalulekile ukuphatha it ngokunakekela ngenxa yobuthi bayo kanye nemvelo engase ibe yingozi.Izinyathelo zokuphepha ezifanele, ezihlanganisa ukusetshenziswa kwezinto zokuzivikela kanye nokusebenza endaweni enomoya omuhle, kufanele zilandelwe ukuze kuqinisekiswe ukuphepha komsebenzisi futhi kuvinjwe noma yikuphi ukuchayeka ngengozi.Kafushane, i-2,2,2-trifluoroethanol iyinhlanganisela ehlukahlukene. ethola ukusetshenziswa okuningi ezimbonini ezahlukene.Ikhono layo lokusebenza njenge-solvent, i-reagent, ne-ejenti yokuxazulula i-chiral iyenza ibe wusizo ezinhlelweni ezihlukahlukene, okuhlanganisa ukuthuthukiswa kwezidakamizwa kanye nokuhlanganiswa kwezinto.Kodwa-ke, kufanele kuqashelwe uma uyisebenzisa, kulandelwa imigomo efanele yokuphepha ukuze kuqinisekiswe inhlalakahle yomsebenzisi kanye nempumelelo yezinqubo zamakhemikhali ezifunwayo.