Imikhiqizo

Inhlanganisela (2S,3R,4R,5S,6R)-2-[4-Chloro-3-(4-ethoxybenzyl)phenyl]-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol i-molecule eyinkimbinkimbi enezinto ezibalulekile ezingase zisetshenziswe emkhakheni we-chemistry kanye ne-pharmacology.Okunye okungase kube khona ukusetshenziswa kwalesi sakhi kumkhakha wamakhemikhali okwelapha.Ukuba khona kwamaqembu e-chloro, ethoxybenzyl, kanye ne-hydroxymethyl kunikeza ithuba lokuhlola ukusebenzisana kwenhlanganisela nezinto ezihlosiwe zebhayoloji futhi kuhlolwe amandla ayo njenge-ejenti yokwelapha.Isakhiwo saleli khemikhali siphakamisa ukuthi singaba nomsebenzi wekhemisi noma sibonise amandla okutholwa kwezidakamizwa.Abacwaningi bangenza izifundo ezehlukene, okuhlanganisa ukuhlolwa kwe-in vitro kanye ne-vivo, ukuhlola umsebenzi webhayoloji wenhlanganisela, indlela yokusebenza, namandla okwelapha.I-stereochemistry eyingqayizivele yenhlanganisela, enenhlanganisela yokucushwa kuka-S no-R, ingase ibe nomthelela emsebenzini wayo wezinto eziphilayo, iyenze ibe i-molecule ethakazelisayo ukuze kuqhutshekwe nophenyo.Ukwengeza, ukwakheka okuyinkimbinkimbi kwenhlanganisela kunikeza amathuba ekhemikhali yezinto eziphilayo zokwenziwa.Abacwaningi bangasebenzisa le nhlanganisela njengesiqalo sokuhlanganiswa kwama-molecule ayinkimbinkimbi noma okuphuma komkhiqizo wemvelo.Ngokwenza izinguquko ezikhethiwe emaqenjini asebenzayo e-molecule, osokhemisi bangathola izinhlanganisela ezinezakhiwo ezifiselekayo, njengokusebenza kahle kwemithi okuthuthukisiwe, ukunyibilika okuthuthukisiwe, noma ubuthi obuncishisiwe.Ukuba khona kweqembu le-hydroxymethyl kuvula amathuba okuqhubeka nokulungiswa, njengokuyiguqula ibe amaqembu ahlukahlukene asebenzayo, okuvumela ukulungiswa komtapo wezincwadi ohlukahlukene wezinhlanganisela zezinhlelo zokusebenza ezihlukahlukene.Ngaphezu kwalokho, amandla ekhompompi njengebhlokhi yokwakha i-chiral ekuhlanganiseni kwe-asymmetric. akufanele indiva.Ukuba khona kwezikhungo eziningi ze-chiral ku-molecule kuvumela ukulungiswa kwezinhlanganisela ezihlanzekile ze-enantiomerically, ezibalulekile embonini yezemithi.Osokhemisi bezinto eziphilayo bangahlola usizo lwenkomponi ekwakheni ama-molecule e-chiral ayinkimbinkimbi, okungase kuholele ekutholakaleni kwemithi emisha noma ekuthuthukisweni kwezindlela zokwenziwa zenoveli.Kubalulekile ukuqaphela ukuthi ukusebenza nale nhlanganisela kudinga ubuchwepheshe ekuphatheni nasekuhlanganiseni ama-molecule e-organic ayinkimbinkimbi.Abacwaningi kufanele baqaphe futhi balandele izimiso zokuphepha ezifanele kuyo yonke inqubo, kusukela ekuhlanganiseni kuya ekwenziweni abalingisi nasekuphathweni.Kafushane, (2S,3R,4R,5S,6R) -2-[4-Chloro-3-(4-ethoxybenzyl) phenyl]-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol ibonisa amandla abalulekile kukhemikhali yezokwelapha, i-synthetic organic chemistry, kanye nokuhlanganiswa kwe-asymmetric.Isakhiwo sayo esiyingqayizivele kanye ne-stereochemistry evulekile izindlela zokuqonda umsebenzi wayo webhayoloji, ukuklama ama-ejenti amasha okwelapha, kanye nokuthuthukisa amasu okwenziwa okwakhiwa kwama-molecule ayinkimbinkimbi.Ukuhlolwa okuqhubekayo kwezakhiwo nokwenziwa kwale nhlanganisela kungase kube nomthelela ekuthuthukisweni kokuthuthukiswa kwezidakamizwa, ukuhlanganiswa kwamakhemikhali, kanye nokuqonda amasistimu ebhayoloji.