Imikhiqizo

I-3-Methyl-7-(2-butyn-1-yl)-8-bromoxanthine iyinhlanganisela yamakhemikhali eyingxenye yomndeni we-xanthine.I-Xanthine derivatives icutshungulwe kakhulu futhi yaziwa ngohlu lwazo oluhlukahlukene lwezinhlelo zokusebenza, ikakhulukazi emkhakheni we-pharmacology.Ukusetshenziswa okukodwa okubalulekile kwe-3-Methyl-7-(2-butyn-1-yl) -8-bromoxanthine ukusetshenziswa kwayo okungaba khona. njengomuthi wokwelapha izimo zokuphefumula njengesifuba somoya kanye nesifo esingamahlalakhona sokuphefumula kwamaphaphu (COPD).I-Xanthine derivatives, okuhlanganisa ne-theophylline, kade yasetshenziswa emithini yokuphefumula ngenxa yezakhiwo zayo zokunqanda ukuvuvukala ne-bronchodilatory.Lezi zinhlanganisela zisebenza ngokuphumuza imisipha ebushelelezi emigwaqweni yomoya kanye nokunciphisa ukuvuvukala, ngaleyo ndlela kuthuthukise umsebenzi wokuphefumula.Ukwengezwa kwe-athomu ye-bromine endaweni yesi-8 yendandatho ye-xanthine ku-3-Methyl-7-(2-butyn-1-yl) -8-bromoxanthine ingathuthukisa imiphumela yayo ye-bronchodilatory uma iqhathaniswa nezinye izinto eziphuma ku-xanthine.Ukufakwa esikhundleni se-Bromine kumakhompiyutha afanayo kuye kwaboniswa ukwandisa amandla abo kanye nobude besenzo.Ngakho-ke, lesi sakhi singase sibe namandla njenge-bronchodilator ephumelelayo futhi ehlala isikhathi eside ezimweni zokuphefumula.Ngaphezu kwalokho, i-xanthines nayo iye yaphenywa ngenxa yezakhiwo zayo ezingase zibe ne-neuroprotective.Baye babonisa imiphumela ye-antioxidant ne-anti-inflammatory, kanye nekhono lokuthuthukisa ukugeleza kwegazi lobuchopho nokuthuthukisa umsebenzi wokuqonda.Lezi zakhiwo zibenza babe abantu abathakazelayo bezinkinga ze-neurodeergenerative ezifana ne-Alzheimer's and Parkinson's disease.Ngaphezu kwezicelo zemithi, i-3-Methyl-7-(2-butyn-1-yl) -8-bromoxanthine ingase futhi ithole ukusetshenziswa ocwaningweni lwesayensi.I-Xanthine derivatives ivame ukusetshenziswa njengamathuluzi e-biochemical okutadisha ama-adenosine receptors nama-phosphodiesterase enzymes.Lezi zinhlanganisela zingasebenza njengama-ligand noma ama-inhibitors akhethiwe, asize ekuphenyweni kwezinqubo ezithile zamangqamuzana kanye nezindlela. lungiselela izakhiwo zayo ezinhlelweni ezithile.Ukusabela kwamakhemikhali okuhlukahlukene, njengokushintshanisa, ukuhlanganisa, nokuhlanganisa, kungasetshenziswa ukwethula amaqembu asebenzayo noma ukuguqula isakhiwo esiwumongo.Lezi zinguquko zingase zithuthukise imisebenzi yayo yemithi noma zinike amandla ukuthuthukiswa kokuphuma kokunye ngokukhetha okuthuthukisiwe kanye ne-bioavailability.Ekuphetheni, i-3-Methyl-7-(2-butyn-1-yl) -8-bromoxanthine inamandla amakhulu okusetshenziswa emithini yokuphefumula. , i-neuroprotection, kanye nocwaningo lwe-biochemical.Imiphumela yayo ye-bronchodilatory iyenza ibe umuntu othembisayo ekwelapheni izimo zokuphefumula, futhi izici zayo ezingase zibe yi-neuroprotective ziphakamisa ukuthi zisetshenziswe ezifweni ze-neurodegenerative.Ucwaningo oluqhubekayo nokuthuthukiswa kuyodingeka ukuhlola ngokugcwele nokusebenzisa izinzuzo zale nhlanganisela emikhakheni eyahlukene yezokwelapha nesayensi.