Imikhiqizo

I-3,4,5-Trifluorophenylboronic acid iyinhlanganisela yamakhemikhali esebenza emikhakheni ehlukahlukene, okuhlanganisa i-organic synthesis, i-chemistry yezokwelapha, nesayensi yezinto zokwakha.Le nhlanganisela isuselwa ku-benzene, enama-athomu amathathu e-fluorine (-F) kanye neqembu elisebenzayo le-boronic acid (-B(OH)2) elinamathiselwe endaweni 3, 4, no-5 yeringi ye-phenyl.Okunye ukusetshenziswa okuyinhloko kuka-3 ,4,5-Trifluorophenylboronic acid iyisivikelo sokwakha esiguquguqukayo ekuhlanganiseni kwezinto eziphilayo.Iqembu le-boronic acid lingabhekana nokusabela okuhlukahlukene, njengokusabela kokuhlangana kwe-Suzuki-Miyaura, okuvumela ukwakheka kwamabhondi e-carbon-carbon.Lokhu kusabela kusetshenziswa kabanzi ekuhlanganisweni kwama-molecule e-organic eyinkimbinkimbi, okuhlanganisa imithi, amakhemikhali ezolimo, namakhemikhali akhethekile.Ngokuhlanganisa i-3,4,5-Trifluorophenylboronic acid ekuphenduleni, osokhemisi bangakwazi ukwethula iqembu le-trifluoromethyl endaweni oyifunayo, okungaba nomthelela omkhulu kumakhemikhali we-compound kanye nezinto eziphilayo. ekuthuthukisweni kwamakhandidethi amasha ezidakamizwa.Ukuba khona kweqembu le-trifluoromethyl kungathuthukisa i-lipophilicity ye-compound, ukuzinza kwe-metabolic, kanye nokubopha amaprotheni, kuyenze ibe ithuluzi elibalulekile lokushintsha izakhiwo zezidakamizwa.Ukwengeza, i-boronic acid ibonise umsebenzi wokulwa nezifo ezinjengomdlavuza, isifo sikashukela, nokuphazamiseka kokuvuvukala.Ngokuhlanganisa i-trifluorophenylboronic acid motif, abacwaningi bangakha izinhlanganisela zenoveli eziphethe kokubili i-boronic acid kanye ne-trifluoromethyl pharmacophores, okungase kuholele ekusebenzeni okuthuthukisiwe nokukhetha kumaphrojekthi okuthola izidakamizwa.Ngaphezu kwalokho, izakhiwo eziyingqayizivele ze-3,4,5-Trifluorophenylboronic acid zikwenza kube usizo. ekusetshenzisweni kwesayensi yezinto.Imvelo yeqembu le-trifluoromethyl yokuhoxiswa kwe-electron ingaba nomthelela ekuzinzeni kwenhlanganisela nokusebenza kabusha.Lesi sici sivumela inhlanganisela ukuthi ibambe iqhaza ekuphenduleni okuhlukahlukene kwe-polymerization, okuholela ekwakhekeni kwama-polymers akhethekile anezakhiwo ezithuthukisiwe, njengokunyuka kokuqina okushisayo noma ukunamathela okuthuthukisiwe.Ukwengeza, ikhono leqembu le-boronic acid lokwakha ukusebenzisana okubuyisela emuva nama-diols noma ama-boronic esters angasetshenziswa ekwakhiweni kwezinto ezisabelayo, njengama-hydrogel, izinto zokuzwa, nezinhlelo zokulethwa kwezidakamizwa.Lapho usebenza ne-3,4,5-Trifluorophenylboronic acid, ukuphathwa okufanele kanye nezinyathelo zokuphepha kufanele zithathwe.Lesi sithako siyazwela emoyeni nasemanzini, futhi kufanele sigcinwe endaweni epholile neyomile.Izinto zokuzivikela, ezifana namagilavu ​​nezibuko, kufanele zigqokwe, futhi izindawo zokusebenza kufanele zingene umoya ngokwanele.Amaqembu ayo asebenzayo we-trifluoromethyl kanye ne-boronic acid ayenza ibe yibhulokhi yokwakha eguquguqukayo ekuhlanganiseni kwe-organic, okuvumela ukuhlanganiswa kwezakhiwo eziyingqayizivele kuma-molecule aqondiwe.Ukusetshenziswa kwayo kukhemikhali yezokwelapha kanye nesayensi yezinto ezibonakalayo igqamisa amandla ayo okutholwa kwezidakamizwa kanye nokuthuthukiswa kwezinto ezithuthukisiwe.Ngokuqhubeka nokuhlola izakhiwo nokusebenza kabusha kwe-3,4,5-Trifluorophenylboronic acid, abacwaningi bangadalula izinhlelo zokusebenza ezintsha ezifaka isandla ekuthuthukisweni kwezifundo eziningi.