Imikhiqizo

(3aR,7aR)-4-(benzo[d]isothiazol-3-yl)octahydrospiro[isoindole-2,1-piperazin]-2-ium4-methylbenzenesulfonate, ebuye ibizwe ngokuthi i-BISO eyakhiwe, iyinhlanganisela yamakhemikhali ene- isakhiwo esiyingqayizivele esivumela ukusetshenziswa okuningana okungase kube khona emkhakheni wamakhemikhali ezokwelapha kanye nokuthuthukiswa kwezidakamizwa.Okunye okungase kube kusetshenziswa i-BISO ekwelapheni ukuphazamiseka kwemizwa.Ukuba khona kwe-benzo[d]isothiazol-3-yl moiety esakhiweni sayo kuphakamisa ukuthi i-BISO ingase ibe nokusebenzisana nezinhlelo ezithile ze-neurotransmitter ebuchosheni, njenge-glutamate noma izinhlelo ze-GABAergic.Lezi zinhlelo ze-neurotransmitter ziyathinteka ezinkingeni eziningi zemizwa njengesithuthwane, ukukhathazeka, nokuphazamiseka kwemizwa.Abacwaningi bangahlola amandla e-BISO okushintsha lezi zinhlelo futhi bakhe ama-ejenti amanoveli okwelapha ezimweni zemizwa. Ngaphezu kwalokho, isakhiwo esiyinhloko se-BISO's spiro[isoindole-2,1-piperazin] sinamandla okusetshenziswa ekwakhiweni kwemithi eqondiswe ezinhlobonhlobo eziningi zemithi. okuhlosiwe kwebhayoloji.Ukuma kwayo okunezinhlangothi ezintathu kanye nokuba khona kwamaqembu asebenzayo kungasebenzisana nama-receptors athile noma ama-enzyme, okuvumela ukuklanywa kwemithi ekhethiwe nenamandla.Abacwaningi bangasebenzisa le motif yesakhiwo ukuze bakhe ama-molecule amancane aqondise ama-receptors abandakanyeka ezifweni ezihlukahlukene, njengomdlavuza, ukuphazamiseka kwenhliziyo nemithambo yegazi, noma izifo ezithathelwanayo.Ngaphezu kwalokho, ukwakheka kwe-spirocyclic ye-BISO kanye neqembu le-ammonium elikhokhiswayo likwenza kube ikhandidethi elinamandla lezinhlelo zokulethwa kwezidakamizwa.Ukuba khona kweqembu elikhokhisiwe kuvumela ukwakheka kwezakhiwo ze-ionic ezinama-molecule akhokhiswa kabi, njengama-nucleic acid noma amaprotheni.Lezi zinkimbinkimbi zingenza kube lula ukulethwa okuhlosiwe kwama-molecule e-bioactive kumaseli noma izicubu ezithile, kuthuthukise ukusebenza kahle kokwelapha kuyilapho kuncishiswa imiphumela engemihle yesistimu.Kubalulekile ukuqaphela ukuthi ukusetshenziswa okungenzeka kwe-BISO kuyaqagela futhi kudinga ucwaningo olwengeziwe nokuthuthukiswa.Isakhiwo sayo esiyingqayizivele sinikeza amathuba osokhemisi bezokwelapha ukuhlola izici zayo zesayensi yemithi kanye nokwandisa amandla ayo okutholakala kwezidakamizwa. Njenganoma iyiphi inhlanganisela yamakhemikhali, ukusetshenziswa kwe-BISO kufanele kuhambisane nezimiso zokuphepha ezimisiwe nemihlahlandlela.Abacwaningi kufanele baqaphele ngesikhathi sokuhlanganisa, ukuphatha, nokugcinwa ukuze kuqinisekiswe ukuphepha nokunciphisa izingozi.Ekuphetheni, (3aR,7aR) -4-(benzo[d]isothiazol-3-yl)octahydrospiro[isoindole-2,1-piperazin. ]-2-ium4-methylbenzenesulfonate, noma i-BISO, inesithembiso sezinhlelo zokusebenza ezihlukahlukene kukhemikhali yezokwelapha nokuthuthukiswa kwezidakamizwa.Isakhiwo sayo esiyingqayizivele sinikeza amathuba okutholwa kwama-ejenti amasha okwelapha, amasistimu okulethwa kwezidakamizwa okuhlosiwe, kanye nokuguqulwa kwezinhlelo ze-neurotransmitter.Kodwa-ke, ucwaningo olunzulu luyadingeka ukuze kucaciswe ngokugcwele amandla alo kanye nokwandisa ukusetshenziswa kwalo emkhakheni wezokwelapha.