Imikhiqizo

(3R,4R)-1-(tert-Butoxycarbonyl)-4-methylpyrrolidine-3-carboxylic acid, eyaziwa nangokuthi i-Boc-4-methylproline, iyinhlanganisela yamakhemikhali esetshenziswa kabanzi emkhakheni we-organic synthesis, ikakhulukazi ekukhiqizeni ama-peptides kanye ne-peptidomimetics yezinhlelo zokusebenza ezihlukahlukene.Okunye ukusetshenziswa okuyinhloko kwe-Boc-4-methylproline njengeqembu elivikelayo leqembu le-amino lama-amino acid ngesikhathi sokuhlanganiswa kwe-peptide.Amaqembu okuvikela ayizinguquko zesikhashana ezivikela amaqembu athile asebenzayo ama-molecule ukuvimbela ukusabela okungafuneki phakathi nenqubo yokwenziwa.Ku-peptide synthesis, i-Boc-4-methylproline isetshenziswa njengeqembu elivikelayo leqembu le-amine, okuvumela ukunamathiselwa okukhethiwe kwamanye ama-amino acid ukuze enze ukulandelana kwe-peptide oyifunayo.I-Boc-4-methylproline iphinde isebenze njenge-chiral building block in the ukuhlanganiswa kwenhlanganisela ehlukahlukene nemisebenzi engaba khona yezinto eziphilayo.Njengenhlanganisela ye-chiral, ine-stereocenter, ekhiqiza ama-enantiomers amabili: (3R,4R) -Boc-4-methylproline kanye (3S,4S) -Boc-4-methylproline.I-enantiomer ngayinye ingase ibonise izakhiwo ezihlukene zemithi nokusebenzisana nokuhlosiwe kwebhayoloji.Ngokusebenzisa i-Boc-4-methylproline njengento yokuqala, osokhemisi bangakwazi ukufinyelela uchungechunge lwezinhlanganisela ze-chiral ukuze kutholwe izidakamizwa nokuthuthukiswa.Ngaphezu kwalokho, okuphuma ku-Boc-4-methylproline kuye kwabonisa imisebenzi ye-antimicrobial, antiviral, kanye ne-anticancer.Lezi zinhlanganisela ziye zaphenywa ukuthi zingaba namandla yini njengama-ejenti okwelapha ngokumelene namagciwane ahlukahlukene, okuhlanganisa amagciwane, amagciwane, namaseli omdlavuza.Ngokushintsha ukwakheka kwe-Boc-4-methylproline kanye nokuhlola okuphuma kuyo, abacwaningi bangahlola amandla abo njengezinhlanganisela eziholayo noma ama-molecule e-scaffold okwakhiwa kwezidakamizwa.Ngaphezu kokusetshenziswa kwayo ekuhlanganiseni kwe-peptide nokuthuthukiswa kwezidakamizwa, i-Boc-4-methylproline nayo iyasetshenziswa. ekudalweni kwe-peptidomimetics.I-Peptidomimetics izinhlanganisela ezilingisa ukwakheka nokusebenza kwama-peptide kodwa ezinokuqina okuthuthukisiwe kanye nezakhiwo ze-pharmacokinetic.I-Boc-4-methylproline ingasebenza njengesakhiwo ekwakhiweni nasekuhlanganiseni i-peptidomimetics, evumela ukuthuthukiswa kwezindlela zokwelapha ezinoveli ezinokutholakala kwe-bioavailability okuthuthukisiwe kanye nokucaciswa okuhlosiwe.Ngokufingqa, (3R,4R) -1-(tert-Butoxycarbonyl)- I-4-methylpyrrolidine-3-carboxylic acid, noma i-Boc-4-methylproline, iyinhlanganisela eguquguqukayo esetshenziswa kabanzi ku-organic synthesis.Iqhaza layo njengeqembu elivikelayo ekuhlanganiseni kwe-peptide, kanye nezakhiwo zayo zokushibilika, kuyenza ibe yisakhiwo esiyigugu sokwakha ama-peptide, ama-peptidomimetics, kanye nezinhlanganisela ze-chiral.Ukuphuma kokuphuma kwe-Boc-4-methylproline kuyaphenywa ngemisebenzi yazo engaba khona yebhayoloji, ehlanganisa izakhiwo ezilwa namagciwane, i-antiviral, kanye ne-anti-cancer.Ucwaningo oluqhubekayo kanye nokuqamba okusha ekusebenziseni i-Boc-4-methylproline ekwakhiweni kwezidakamizwa kunomthelela ekwakhiweni kwama-ejenti amasha okwelapha futhi kuthuthukise ukuqonda kwethu izinqubo zebhayoloji eziyinkimbinkimbi.