Imikhiqizo

(3R,4S,5R,6R)-3,4,5-tris(triMethylsilyloxy)-6-((triMethylsilyloxy)Methyl)tetrahydro-2H-pyran-2-one, eyaziwa nangokuthi i-TBDMS-protected tetrahydro-2H-pyran -2-one, iyinhlanganisela evame ukusetshenziswa ku-organic synthesis nanjengeqembu elivikelayo emkhakheni we-chemistry.Olunye uhlelo olubalulekile lwe-TBDMS-protected tetrahydro-2H-pyran-2-one ukusetshenziswa kwayo njengebhulokhi yokwakha ekuhlanganiseni ama-molecule e-organic eyinkimbinkimbi.I-compound inezindawo eziningi ezisebenzayo ezingabhekana nezinguquko ezihlukahlukene zeqembu.Iqembu elivikelayo le-TBDMS (tert-butyldimethylsilyl) elikhona ku-molecule linikeza ukuzinza futhi livumela ukuguqulwa okukhethiwe kwamaqembu athile asebenzayo.Lokhu kuguquguquka kwenza i-TBDMS-evikelwe i-tetrahydro-2H-pyran-2-one ibe isimaphakathi esibalulekile ekuhlanganisweni kwemikhiqizo yemvelo, imithi, namanye amakhemikhali amahle.Okunye ukusetshenziswa okubalulekile kwe-TBDMS-protected tetrahydro-2H-pyran-2-one yayo indima njengeqembu elivikela utshwala nama-amine ku-organic synthesis.Iqembu le-TBDMS lingangezwa ngokukhetha kumaqembu e-hydroxyl noma ama-amino, liwafice ngempumelelo phakathi nezinyathelo zokusabela ezihlukahlukene.Lesi sivikelo sivimbela ukusabela okuseceleni okungafuneki futhi siqinisekisa uguquko olufiswayo lwenzeka kumasayithi afiswayo.Uma ukusabela okufunayo sekuqediwe, iqembu le-TBDMS lingasuswa kalula, liveze i-hydroxyl yasekuqaleni noma iqembu le-amino ngaphandle kokuthinta ezinye izinto zokusebenza ku-molecule.I-TBDMS-protected tetrahydro-2H-pyran-2-one iphinde ithole isicelo njenge-ejenti evikelayo. ama-carbohydrate.Ivumela ukuvikelwa okukhethiwe kwamaqembu e-hydroxyl kuma-molecule kashukela ngesikhathi sokuphendula kwe-glycosylation, okuvumela ukuhlanganiswa kwama-glycans ayinkimbinkimbi nama-glycosides.Lelisu lokuvikela libaluleke kakhulu kumakhemikhali we-carbohydrate, lapho amaqembu amaningi e-hydroxyl ekhona futhi kudingeka ukukhethwa kabusha okuqondile kwe-TBDMS.Ngaphezu kwalokho, i-TBDMS-evikelwe i-tetrahydro-2H-pyran-2-one isetshenziswa ekulungiseleleni ama-polymers asebenzayo.I-compound ingafakwa ezakhiweni ze-polymer, inikeze amasayithi asebenzayo ukuze kulungiswe okunye kanye nokusabela okuxhumanisayo.Lokhu kuvumela ukwakhiwa kwezinto ze-polymer ezinezakhiwo ezihambisanayo nokusebenza, njengokuzinza okuthuthukisiwe, ukuhambisana kwezinto eziphilayo, nokukhishwa kwezidakamizwa okulawulwayo. -((triMethylsilyloxy)Methyl)tetrahydro-2H-pyran-2-one, noma i-TBDMS-protected tetrahydro-2H-pyran-2-one, iyinhlanganisela eguquguqukayo enezinhlelo zokusebenza ezihlukahlukene ku-organic synthesis, ikakhulukazi njengebhulokhi yokwakha neqembu elivikelayo. .Ikhono layo lokuvikela ngokukhetha amaqembu asebenzayo kanye nokwenza lula ukuguqulwa kwamangqamuzana ayinkimbinkimbi kwenza kube ithuluzi elibalulekile emkhakheni wamakhemikhali.Ucwaningo oluqhubekayo nokuhlolwa kwezinhlelo zalo zokusebenza kungase kuveze okunye ukusetshenziswa futhi kube negalelo ekuthuthukisweni kwamakhemikhali okwenziwa kanye nesayensi yezinto ezibonakalayo.