Imikhiqizo

I-compound 4-[4-[(5S)-5-(aminomethyl)-2-oxo-3-oxazolidinyl]phenyl]-3-morpholinone hydrochloride iwuhlobo oluthile lwenhlanganisela echazwe ekuphenduleni kwangaphambilini, lapho iku uhlobo losawoti we-hydrochloride.Ifomu likasawoti we-hydrochloride livame ukusetshenziswa emikhakheni yezemithi ngenxa yokuzinza kwalo okuthuthukisiwe, ukuncibilika, kanye nokwakheka kalula.Le nhlanganisela inezici ezimbalwa ezithakazelisayo zesakhiwo ezenza ibaluleke kakhulu ekusetshenzisweni komuthi.Ukuba khona kwamaqembu e-oxazolidinyl kanye ne-morpholinone kuphakamisa ukusebenzisana okungenzeka okuhlosiwe okuqondile kwezinto eziphilayo, okwenza kube yisakhiwo esibalulekile ekutholakaleni nasekuthuthukisweni kwezidakamizwa.Iqembu le-oxazolidinyl lingatholakala kuma-antibacterial ahlukahlukene futhi liyaziwa ngomsebenzi walo ngokumelene namabhaktheriya amelana nezidakamizwa.Le nhlanganisela ingase isize ukunqoba ukwanda kokumelana nama-antibiotic ngokukhomba izifo ezibangelwa amagciwane okunzima ukuwelapha.I-morpholinone moiety, ngakolunye uhlangothi, isetshenziswe kakhulu kumakhemikhali okwelapha ngenxa yekhono layo lokusebenzelana nemigomo yezinto eziphilayo.Ukuba khona kweqembu le-aminomethyl ku-morpholinone kuphakamisa amandla okuxhumana okwengeziwe kanye nokucaciswa okuthile ekubopheni okuhlosiwe.Ngokucabangela ukwakheka kwenhlanganisela, kungase kube nezinhlelo zokusebenza njenge-ejenti elwa namagciwane noma elwa namagciwane.Ucwaningo olwengeziwe luyadingeka ukuze kutholwe indlela yayo ethile yokwenza kanye nalokho okungase kube okuhlosiwe.Ukwengeza, izakhiwo ze-pharmacokinetic kanye ne-toxicological ye-compound zidinga ukuhlolwa ukuze kutholwe ukusebenza kwayo kanye namaphrofayili okuphepha.Eyakhiwe njengosawoti we-hydrochloride, ukuncibilika kwe-compound kuyathuthukiswa, okwenza kube ngokufaneleka kakhulu ekuphathweni komlomo.Ifomu likasawoti liphinde livumele ukwakheka kalula kumafomu omthamo njengamaphilisi noma amaphilisi.Kafushane, inhlanganisela 4-[(5S) -5-(aminomethyl)-2-oxo-3-oxazolidinyl]phenyl] -3- i-morpholinone hydrochloride ikhombisa amandla emkhakheni wezokwelapha, ikakhulukazi njenge-ejenti elwa namagciwane noma elwa namagciwane.Izici zayo zesakhiwo kanye nefomu likasawoti we-hydrochloride kuyenza ibe ikhandidethi elikhangayo lokucwaninga nokuthuthukiswa okuqhubekayo.Kodwa-ke, ucwaningo olwengeziwe luyadingeka ukuze kutholwe ukusetshenziswa kwayo okuqondile, izindlela zokwenza, kanye namaphrofayili okuphepha nokusebenza ngempumelelo ngaphambi kokuba isetshenziswe njenge-ejenti yokwelapha.