4-Amino-1-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one Cas:951-77-9
| Inombolo Yekhathalogi: | XD90580 |
| I-Cas: | 951-77-9 |
| I-Molecular Formula: | I-C9H13N3O4 |
| Isisindo se-Molecular: | 227.22 |
| Ukutholakala: | Kukhona kusitoki |
| Inani: | |
| I-Prepack: | 1g USD10 |
| Iphakethe lenqwaba: | Cela i-Quote |
Ukucaciswa Komkhiqizo
| Ukubukeka | I-crystalline powder emhlophe |
| Isivivinyo | 99% |
| I-Melting Point | 196°C - 200°C |
I-Thymidine phosphorylase (TP, EC 2.4.2.4) ibone ukwakheka kwe-substrate enemininingwane ephezulu, ngokusebenzisa kokubili isisekelo kanye nezingxenye ze-ribosyl.Ukushintshwa kwe-3'-OH ye-thymidine kube nomthelela ngokuphawulekayo emsebenzini wayo we-catalytic nge-TP.Ukuguqulwa kwama-nucleosides e-pyrimidine anezingxenye eziyisisekelo ezishintshiwe zibe ifomu elihambisana ne-1-phosphate kwakungekuhle.Umsebenzi weqembu elishiyayo wehla ngokunyuka kwephunga elimnandi le-pyrimidine base moiety, ngenxa yobunzima obandayo bokuhlukanisa isisekelo ngama-amino acid asendaweni kuya endaweni esebenzayo.Ukushintshwa kwamaqembu asebenzayo angu-3' no-5' kuvame ukwehlisa izinga lokusabela kanye nokuguqulwa kwephesenti nge-TP.Ikakhulukazi iqembu le-ribosyl 3' hydroxyl lalibalulekile ngokwesakhiwo ukuze kuboshwe i-substrate yi-enzyme.I-kinetic assay ibonise ngokucacile amanani aphezulu we-K(m) kanye ne-V(max) aphansi ekushintsheni iqembu le-3' hydroxyl nge-hydrogen.
