Imikhiqizo

I-4-Carboxyphenylboronic acid iyinhlanganisela yemvelo eyingxenye yomndeni wama-boronic acid.Isakhiwo sayo samakhemikhali siqukethe i-athomu ye-boron exhunywe eqenjini le-carboxyphenyl.Le nhlanganisela ithole izinhlelo zokusebenza eziningi emikhakheni ehlukahlukene efana ne-organic synthesis, isayensi yezinto zokwakha, i-chemistry yezokwelapha, kanye ne-catalysis.Okunye okubalulekile kwe-4-Carboxyphenylboronic acid kusendaweni ye-organic synthesis.Ivamise ukusetshenziswa njenge-reagent ku-palladium-catalyzed cross-coupling reactions, ikakhulukazi ku-Suzuki-Miyaura kanye ne-Chan-Lam yokusabela kokuhlanganisa.Ngokubamba iqhaza njengomthombo we-boron, ingakha ibhondi ye-carbon-carbon nama-substrates ephilayo, njenge-aryl noma i-vinyl halides.Lokhu kuvumela osokhemisi ukuthi bakhe ama-molecule ezinto eziphilayo eziyinkimbinkimbi kanye nezinhlanganisela ezisebenza kahle.Ikhono lokwethula iqembu le-carboxyphenyl linikeza ukuguquguquka ekuguquleni nasekuhlanganiseni izakhiwo zezinhlanganisela eziwumphumela.Ekhemistri yezokwelapha, i-4-Carboxyphenylboronic acid ithola ukusetshenziswa ekwakhiweni nasekuhlanganiseni kwama-molecule asebenzayo.Ivumela ukwethulwa kwe-boronic acid moiety, enikeza izici eziyingqayizivele kanye nokusebenza kabusha kwezinhlanganisela ezihlosiwe.Isibonelo, ama-boronic acid angasebenza njengama-protease inhibitors, futhi ngokuhlanganisa iqembu le-carboxyphenylboronic acid, abacwaningi bangakwazi ukuguqula umsebenzi we-enzyme noma baklame ama-enzyme-targeted inhibitors.Ngaphezu kwalokho, ukuba khona kweqembu le-carboxylic acid kwenza inhlanganisela yakhe izibopho ze-hydrogen nama-biomolecules, ithuthukise ukuhlobana kwayo nama-protein receptors, ngaleyo ndlela ibe nomthelela ekusebenzeni kwawo kwezinto eziphilayo. izibopho ezinama-polyols noma izinhlanganisela eziqukethe i-hydroxyl.Lesi sakhiwo sivumela ukuthi sisetshenziswe njengengxenye ekuhlanganisweni kwezinto ezithuthukisiwe njengama-hydrogel, ama-bioconjugates, noma ama-polymers asabelayo.Ngokufaka i-4-Carboxyphenylboronic acid kulezi zinto, izakhiwo zabo zingenziwa ngendlela efanele, zivumela izinhlelo zokusebenza ezifana nezinhlelo zokulethwa kwezidakamizwa, izinzwa, nezinto ezihlakaniphile.Ukwengeza, iqembu le-carboxyphenylboronic acid kule nhlanganisela lenza ukuthi lisebenze njenge-catalyst ekuphenduleni okuningana. .Ingabamba iqhaza ku-acid-base catalysis, esterification, kanye nokusabela kwe-amidation.Lo msebenzi we-catalytic ungasetshenziswa ekuhlanganiseni kwemithi, amakhemikhali amahle, namanye ama-molecule ephilayo.Ekuphetheni, i-4-Carboxyphenylboronic acid iyinhlanganisela eguquguqukayo ethola usizo emikhakheni eyahlukene yesayensi.Izicelo zayo zisukela ku-organic synthesis kanye namakhemikhali okwelapha kuye kwisayensi yezinto zokwakha kanye ne-catalysis.Ikhono layo lokubamba iqhaza ekuhlanganeni kwe-palladium-catalyzed cross-coupling, amandla ayo njengesakhiwo sezinto eziphilayo ezisebenzayo, kanye nendima yayo njenge-catalyst ikwenza kube ithuluzi elibalulekile kubacwaningi ekuphishekeleni ukuthuthukiswa kolwazi nokuthuthukisa izixazululo ezintsha.