Imikhiqizo

I-4-Chloro-2-fluoro-3-methoxyphenylboronic acid iyinhlanganisela yekhemikhali enezinhlelo ezahlukene ze-organic synthesis, chemistry medicinal, and materials science.Okunye ukusetshenziswa okuyinhloko kwe-4-Chloro-2-fluoro-3-methoxyphenylboronic acid ekuguqukeni kokuhlangana kwe-metal-catalyzed cross-coupling.Isebenza njenge-boronic acid building block, evumela ukwakheka kwe-carbon-carbon noma i-carbon-heteroatom bond.Isibonelo, le nhlanganisela ingasetshenziswa ku-Suzuki-Miyaura-cross-coupling reactions, lapho isabela nge-aryl noma i-vinyl halide ngaphansi kwe-palladium catalysis ukuze kukhiqizwe amakhompawundi e-biaryl.Lokhu kusabela okuhlanganayo kusetshenziswa kakhulu ekuhlanganiseni ama-molecule ezinto eziphilayo eziyinkimbinkimbi, okuhlanganisa imithi kanye namakhemikhali ezolimo, kanye nokwakhiwa kwezinto eziphilayo.Inhlanganisela eyingqayizivele ye-chlorine, i-fluorine, namaqembu e-methoxy esakhiweni se-4-Chloro-2 -i-fluoro-3-methoxyphenylboronic acid inika amandla ukuhlanganiswa kokuphuma okuhlukahlukene okunezici ezihlanganisiwe.I-athomu ye-chlorine ingasebenza njengeqembu eliqondisayo kuzinqubo ze-metal-catalyzed zenguquko, iqondise ukusabela ngokukhetha kumasayithi athile ngaphakathi kwe-molecule.Ukufakwa esikhundleni se-fluorine kunikeza i-lipophilicity ethuthukisiwe, engathonya izakhiwo zekhemisi futhi ithuthukise ukutholakala kwayo kwe-bioavailability.Iqembu le-methoxy, ngakolunye uhlangothi, lingenza njengeqembu elivikelayo noma libambe iqhaza ekuguqulweni kwamakhemikhali okuhlukahlukene.Ekhemistri yezokwelapha, i-4-Chloro-2-fluoro-3-methoxyphenylboronic acid kanye nokuphuma kwayo kunesithakazelo njengabangase babe abantu bezidakamizwa.Amaqembu asebenzayo afana ne-chlorine ne-fluorine angakwazi ukulinganisa ukusebenzisana kwekhompiyutha nokuhlosiwe kwebhayoloji futhi athuthukise izici zayo zemithi.Ukwengeza, iqembu le-methoxy lingathuthukisa ukuzinza kwe-metabolic ye-compound futhi libe negalelo ekuzijabuliseni nasekuncibilikeni kwayo.Lezi zakhiwo zenza i-4-Chloro-2-fluoro-3-methoxyphenylboronic acid ibe isiqalo esibalulekile sokuthuthukisa ama-ejenti amasha okwelapha emikhakheni efana ne-oncology, izifo ezithathelwanayo, nokuvuvukala.Ngaphezu kwalokho, i-boronic acid moiety ku-4-Chloro-2-fluoro -3-methoxyphenylboronic acid ingenza kube lula ukwakheka kwe-boronate esters ezinzile, esetshenziswe ekwakhiweni kwezinto ezinezici ezihlukile.Lezi zinsiza zingabonisa izinto ezibonakalayo, ze-elekthronikhi, noma ze-catalytic, kuye ngokwakheka nokwakheka kwazo.Ukufakwa kwe-4-Chloro-2-fluoro-3-methoxyphenylboronic acid noma okuphuma kuyo kulezi zinto kungadlulisela ukusebenza okuthile futhi kuthuthukise ukusebenza kwazo.Kafushane, i-4-Chloro-2-fluoro-3-methoxyphenylboronic acid ithola ukusetshenziswa emikhakheni eyahlukene. ngenxa yamakhemikhali ayo ahlukahlukene kanye namandla okudala ama-molecule asebenzayo nezinto zokwakha.Iqhaza layo ekushintsheni kokuhlangana kwe-metal-catalyzed, kuhlanganiswe nezimpawu ezihlukile zamaqembu ayo asebenzayo, kuyenza ibe ithuluzi elibalulekile ku-organic synthesis kanye namakhemikhali okwelapha.Ukwengeza, i-boronic acid moiety yenza ukwakheka kwe-boronate esters, enomthelela ekuthuthukisweni kwezinto ezithuthukisiwe ezinezakhiwo ezihambisanayo.