Imikhiqizo

I-4-Hydroxyphenylboronic acid pinacol ester, eyaziwa nangokuthi i-HBP ester, iyinhlanganisela yamakhemikhali ethola ukusetshenziswa emikhakheni ehlukahlukene ngenxa yezakhiwo zayo ezihlukile njenge-boronic ester.Isakhiwo sayo samakhemikhali siqukethe i-athomu ye-boron exhunywe eqenjini le-phenolic ngokuxhunyaniswa kwe-ester, okuyenza ibe ibhulokhi yokwakha ebalulekile ye-organic synthesis.Ku-organic synthesis, i-4-Hydroxyphenylboronic acid pinacol ester ivame ukusetshenziswa njenge-reagent yesiphambano se-Suzuki-Miyaura. - ukusabela kokuhlangana.Lokhu kusabela kuhilela ukwakheka kwebhondi ye-carbon-carbon phakathi kwe-aryl noma i-vinyl boronic acid kanye ne-aryl noma i-vinyl halide noma i-triflate.Njenge-boronic ester, i-HBP ester isebenza njengesandulela se-boronic acid ehambisanayo, engakwazi ukubhekana nokusabela okuhlangene okuphambene nama-electrophiles ahlukahlukene, okuholela ekwakhekeni kwama-molecule ezinto eziphilayo eziyinkimbinkimbi.Lokhu kusabela kunokusebenza okubalulekile kukhemikhali yezokwelapha, i-agrochemical synthesis, isayensi yezinto ezibonakalayo, nezinye izindawo eziningi ze-organic synthesis.Ukuguquguquka kwe-HBP ester kusekwazini kwayo ukwenza izinguquko zeqembu ezisebenzayo, ezifana ne-oxidation noma ukunciphisa, ukwethula ukusebenza okwengeziwe ingqamuzana.Isibonelo, iqembu le-hydroxyl le-phenolic moiety lingavikelwa futhi kamuva livinjwe, okuvumela ukuguqulwa okukhethiwe kanye nokuhlukahluka kwenhlanganisela.Lesi sakhiwo senza i-HBP ester ibe ithuluzi elibalulekile ekuhlanganisweni kwemithi, amakhemikhali ezolimo, namanye amakhemikhali amahle.Ngaphezu kwalokho, i-HBP ester ivame ukusetshenziswa ekwakhiweni kwezinzwa zamangqamuzana nama-probe.Ngenxa ye-athomu ye-boron esakhiweni sayo, ingakha ama-complexes ahlehliswayo ngama-diols noma ama-polyols, njengoshukela noma ama-carbohydrate.Lesi sakhiwo sivumela ukuthuthukiswa kwezinzwa ezisekelwe ku-boronate ukuze kutholwe i-glucose, kanye namanye ama-molecule ahlobene nebhayoloji.I-HBP ester ingafakwa ezisekelweni ezihlukene zokuzwa, okuhlanganisa ama-fluorescent noma ama-colorimetric probe, okuhlinzeka ngendlela yokuthola abahlaziyi abathile kumasampula ezinto eziphilayo noma ezemvelo.Ngaphandle kokusetshenziswa kwayo ekuhlanganiseni kwezinto eziphilayo nasezinhlelweni zokuzwa, i-4-Hydroxyphenylboronic acid pinacol ester nayo iye yaphenywa. ngeqhaza elingaba khona ezinhlelweni zokulethwa kwezidakamizwa.I-athomu ye-boron ingabamba iqhaza ekusebenzelaneni nama-biomolecules, njengama-nucleic acid noma amaprotheni, futhi iye yahlolelwa ukulethwa kwezidakamizwa okuhlosiwe, ukutholwa kwamaselula okuthuthukisiwe, noma ukukhululwa okulawulwayo kwama-ejenti okwelapha. esetshenziswa ku-organic synthesis, izicelo zokuzwa, nezinhlelo zokulethwa kwezidakamizwa.Ukusebenza kwayo kwe-boronic ester kuyenza ibambe iqhaza ekuphenduleni kokuhlangana kwe-Suzuki-Miyaura futhi yenze izinguquko zeqembu elisebenzayo, yandise ukusetshenziswa kwayo kokwenziwa.Ukwengeza, i-HBP ester ingakha ama-complexes ahlehliswayo anama-diol, ayenze ibe wusizo ekuthuthukisweni kwezinzwa zamangqamuzana.Amandla ayo ezinhlelweni zokulethwa kwezidakamizwa aphinde agcizelele ukubaluleka kwayo njengenhlanganisela eguquguqukayo emikhakheni eyahlukene yesayensi nezobuchwepheshe.