Imikhiqizo

I-4-Phenoxyphenylboronic acid iyinhlanganisela yamakhemikhali enokusetshenziswa okuhlukahlukene emikhakheni ehlukene, okuhlanganisa nemithi, ucwaningo, kanye ne-organic synthesis.Le nhlanganisela, nokusebenza kwayo kwe-boronic acid, inikeza izici eziningana eziyingqayizivele ezenza kube isisekelo sokwakha esibalulekile ekuthuthukiseni ama-molecule amasha nezinto zokwakha.Okunye okubalulekile kwe-4-Phenoxyphenylboronic acid kusekucwaningweni nasekuthuthukisweni kwemithi.I-Boronic acids ithole ukunakwa embonini yezemithi ngenxa yekhono labo lokwakha izibopho ezihlehliswayo ze-covalent nama-biomolecules athile, njengamaprotheni nama-enzyme.Lesi sakhiwo sivumela ukuklanywa kwezidakamizwa ezisekelwe kwi-boronic acid ezingakhomba ngokukhetha okuhlosiwe kwebhayoloji, njengama-enzyme abandakanyeka ezifweni ezinjengomdlavuza noma isifo sikashukela.Abacwaningi bangasebenzisa i-4-Phenoxyphenylboronic acid njengento yokuqala ukuze bahlanganise ukhetho lwezidakamizwa oluqukethe i-boronic acid futhi bahlole izinhlelo zabo zokusebenza zokwelapha ezingaba khona.Ngaphezu kwemithi, i-4-Phenoxyphenylboronic acid iphinde ithole ukusetshenziswa ekuhlanganiseni kwe-organic.Iqembu le-boronic acid kule nhlanganisela lingabhekana nokusabela okuhlukahlukene, okuhlanganisa ukusabela okuhlangene kwe-Suzuki-Miyaura.Lokhu kusabela kuhlanganisa ukuhlanganisa i-boronic acid ne-organic halides noma ama-triflates ahlukahlukene, okuholela ekwakhekeni kwe-carbon-carbon bond.Lokhu kuguquguquka kuvumela osokhemisi ukuthi bakhe ama-molecule ezinto eziphilayo ayinkimbinkimbi, njengemikhiqizo yemvelo, amakhemikhali ezolimo, nezinto ezithuthukile.I-4-Phenoxyphenylboronic acid isebenza njengesandulela esibalulekile sale mizamo yokwenziwa.Ngaphezu kwalokho, i-4-Phenoxyphenylboronic acid nayo isetshenziswa ekusetshenzisweni kocwaningo, ikakhulukazi emkhakheni we-chemical biology kanye ne-bioconjugation.I-Boronic acids isetshenziswe ekuthuthukiseni ama-fluorescent probes, izinzwa, nama-imaging agents ukuze kutholwe futhi kubonakale ngeso lengqondo ama-biomolecules athile noma imicimbi yeselula.Ngokuhlanganisa i-4-Phenoxyphenylboronic acid ekwakhiweni kwalawa ma-probe, abacwaningi bangakha amathuluzi akhethekile nazwelayo okutadisha izinqubo zebhayoloji ku-vitro kanye ne-vivo. kanye ne-chemical biology.Ukusebenza kwayo kwe-boronic acid kuvumela ukuklanywa kanye nokuhlanganiswa kwamakhandidethi amasha ezidakamizwa anezinzuzo ezingaba khona zokwelapha.Isebenza njengesakhiwo esiwusizo sokwakhiwa kwama-molecule ayinkimbinkimbi.Ukwengeza, ezilungiselelweni zocwaningo, kunomthelela ekwakhiweni kwamathuluzi okutadisha izinqubo zebhayoloji.Sekukonke, i-4-Phenoxyphenylboronic acid iyinhlanganisela ebalulekile, eyenza intuthuko emikhakheni ehlukahlukene yesayensi.