Imikhiqizo

(4R-Cis) -1,1-Dimethylethyl-6-[2-[2-(4-fluorophenyl)-5-(1-methylethyl)-3-phenyl-4--[(phenylamino)carbonyl]-1H-pyrrol -1-yl]ethyl]-2,2-dimethyl-1,3-dioxane-4-acetate iyinhlanganisela enesakhiwo samakhemikhali esiyinkimbinkimbi.Nakuba ulwazi oluqondile mayelana nokusetshenziswa kwalesi sakhi lungase lube nomkhawulo, singaxoxa ngezicelo zayo ezingase zibe khona ngokusekelwe ezicini zayo zesakhiwo kanye nezici ezivamile zamakhompiyutha afanayo.Ukuba khona kwe-dioxane moiety kule nhlanganisela kusikisela ukuthi ingase ibe nezinto ezincibilikayo noma isetshenziswe. njenge-ejenti ye-solubilizing.I-Dioxane iyi-solvent evamile, ikakhulukazi kumakhemikhali ezinto eziphilayo, njengoba ixubana namanzi futhi inokunyibilika okuhle kwezinhlobonhlobo zamamolekyuli ezinto eziphilayo.Ukuba khona kwe-dioxane moiety kule nhlanganisela kubonisa ukuthi ingase ibe nezinto ezifanayo zokuncibilika.Ngaphezu kwalokho, izingxenye zesakhiwo zalesi sakhi, njengamaqembu e-fluorophenyl kanye ne-phenylamino carbonyl, ziphakamisa umsebenzi ongaba khona wezinto eziphilayo.Ukufakwa esikhundleni se-fluorine kuma-organic compounds kungathuthukisa izakhiwo zabo ze-pharmacokinetic, okungenzeka kwandise amandla abo noma i-bioavailability.Ukuba khona kweqembu le-phenylamino carbonyl kungase kubonise amandla okusebenzelana nemigomo yezinto eziphilayo, okungenzeka kuholele emiphumeleni yokwelapha.Ngokusekelwe kulezi zici zesakhiwo, kungenzeka ukuthi le nhlanganisela ingaba nezinhlelo zokusebenza kumakhemikhali emithi noma ekuthuthukisweni kwezidakamizwa.Kungase kubhekwe njengenhlanganisela engase iholele ekwakhiweni kwemithi emisha eqondise ezifweni ezithile.Kodwa-ke, kubalulekile ukuqaphela ukuthi ucwaningo olwengeziwe luyadingeka ukuze kutholwe izici zayo zangempela zesayensi yezokwelapha, okuhlanganisa ukusebenza kwayo, indlela yokusebenza, kanye nemiphumela engemihle engaba khona. noma njengengxenye ekuhlanganiseni kwamakhemikhali.Okuphuma ku-Nitronyl kanye ne-pyrrole kuye kwaphenywa ukuze kusetshenziswe okungase kube khona njengama-conductor, ama-catalysts, noma amabhlogo wokwakha wezakhiwo eziyinkimbinkimbi.Kodwa-ke, lezi zinhlelo zokusebenza zizodinga uphenyo olwengeziwe kanye nokwenza kahle kwezindlela zokuhlanganisa. Sekukonke, inhlanganisela (4R-Cis) -1,1-Dimethylethyl-6-[2--[2-(4-fluorophenyl)-5-(1-) i-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrol-1-yl]ethyl]-2,2-dimethyl-1,3-dioxane-4-acetate ikhombisa amandla okusebenza kukhemikhali yezokwelapha, isayensi yezinto zokwakha, noma i-chemical synthesis.Kodwa-ke, kubalulekile ukwenza ucwaningo olunzulu ukuze kuhlolwe izakhiwo zayo, kuthuthukiswe imizila efanelekile yokuhlanganisa, futhi kunqunywe ukuthi isetshenziswa kanjani kumkhakha ngamunye.