Imikhiqizo

I-5-(Bromomethyl) -4-(4-fluorophenyl) -6-isopropyl-2--[methyl(methylsulfonyl)amino]pyrimidine iyinhlanganisela yamakhemikhali ethola usizo ocwaningweni oluhlukahlukene, kwezemithi, nasezimbonini zokusebenza.Le nhlanganisela yaziwa ngemvelo yayo eguquguqukayo kanye namandla enawo okuthuthukisa ama-molecule nezidakamizwa eziyingqayizivele ngenxa yesakhiwo sayo esithile kanye namaqembu asebenzayo. izidakamizwa.Ukuba khona kwe-athomu ye-bromine, i-athomu ye-fluorine, iqembu le-isopropyl, kanye nesakhiwo sendandatho ye-pyrimidine kwenza kube isakhiwo esikhangayo sokwakha ama-molecule amasha anezindawo ezifunwayo.Osokhemisi nabacwaningi bezokwelapha bangashintsha futhi basebenzise lesi sakhi ukuze sethule ukusebenza okuthile noma izici zesakhiwo ezizuzisa isenzo sezidakamizwa ezihlosiwe noma izakhiwo ze-pharmacokinetic ezithuthukisiwe.Ngaphezu kwalokho, ukuba khona kwamaqembu e-methyl kanye ne-methylsulfonyl ku-compound kwenza kube usizo ku-organic synthesis.Iqembu le-methylsulfonyl lingakwazi ukubhekana nokusabela okuhlukahlukene, njengokususwa kwe-nucleophilic, ukuqedwa, noma i-oxidation, okuvumela ukwethulwa kwamaqembu ahlukene asebenzayo ku-molecule eqondiwe.Lokhu kuguquguquka kwenza kubeluleka ekudaleni inhlanganisela yezinto eziphilayo eziyinkimbinkimbi endaweni yaselabhorethri.Ukwengeza, ukwakheka kwekhompompi kuyenza ibe wusizo olukhulu ezifundweni zocwaningo.I-athomu ye-fluorine nezinye izithako ezithize zingase zibe nomthelela ezakhiweni ezithile zomzimba noma zamakhemikhali, okukwenze kube lula ukuphenya izenzakalo ezithile noma njengenhlanganisela yereferensi yezifundo zokuqhathanisa.Abacwaningi bavame ukusebenzisa izinhlanganisela ezinjalo ukuze baqonde ukusebenzisana kwezinto eziphilayo, i-kinetics yokusabela kocwaningo, bathuthukise izindlela ezintsha zokwenziwa, noma bathuthukise ukusebenza kwezinqubo ezikhona zezimboni.Kubalulekile ukuqaphela ukuthi ukusetshenziswa okuqondile kanye nokusetshenziswa okungenzeka kwe-5-(Bromomethyl) -4-( I-4-fluorophenyl) -6-isopropyl-2--[methyl(methylsulfonyl)amino]pyrimidine ingahluka kuye ngendawo ethile yocwaningo noma imboni.Izicelo ezingase zibe khona zenhlanganisela zidlulela ngale kwalokhu okukhulunywe ngakho ngaphambili, futhi ukuba wusizo kwayo kungase kuhlolwe osokhemisi, izazi zemithi, izazi zamakhemikhali ezinto eziphilayo, nabanye ososayensi ababambe iqhaza ekutholakaleni kwezidakamizwa, isayensi yezinto ezibonakalayo, noma ucwaningo lwamangqamuzana.Kafushane, 5-(Bromomethyl) -4 -(4-fluorophenyl) -6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidine iyinhlanganisela eguquguqukayo enesithembiso ocwaningweni lwezemithi, amakhemikhali, nolwezimboni.Isakhiwo sayo esikhethekile kanye namaqembu asebenzayo ayenza ibe yisakhiwo esikhangayo sokuhlanganisa ama-molecule ezidakamizwa emisha kanye nokuphenya ukusabela okuhlukahlukene kwamakhemikhali.Izicelo ezingase zibe khona zenkomponi zibanzi, futhi ukuhlola okwengeziwe kwezindawo zayo kungase kuvule indlela yentuthuko emikhakheni eminingi yesayensi.