5-Methylphenazinium methosulfate Cas: 299-11-6 99% Okuluhlaza okumnyama kuya kumpushana onsundu
| Inombolo Yekhathalogi | XD90224 |
| Igama Lomkhiqizo | 5-Methylphenazinium methosulfate |
| I-CAS | 299-11-6 |
| I-Molecular Formula | I-C14H14N2O4S |
| Isisindo samangqamuzana | 306.337 |
| Imininingwane Yesitoreji | -15 kuya ku-20 ° C |
| Ikhodi Yentela Evumelanisiwe | 29339980 |
Ukucaciswa Komkhiqizo
| I-Melting Point | 158-160 °C (dec.)(lit.) |
| Isivivinyo | 99% |
| Ifomu | Okuqinile |
| Ukubukeka | Impushana eluhlaza ukuya ensundu |
I-n-3 polyunsaturated fatty acids eicosapentaenoic acid (EPA) kanye ne-docosahexaenoic acid (DHA) kukhonjiswe ukuthuthukisa umphumela wezidakamizwa ze-chemotherapeutic ezifundweni zemitholampilo ezigulini ezinomdlavuza kanye nokwenza i-apoptotic tumor cell death in vitro.Kuze kube manje, i-EPA ne-DHA akukaze kuphenywe ku-myeloma eminingi (MM).Amaseli e-myeloma yabantu (i-L363, i-OPM-1, i-OPM-2 ne-U266) kanye namaseli egazi avamile we-mononuclear egazi avezwa ku-EPA ne-DHA, futhi imiphumela ekusebenzeni kwe-mitochondrial kanye ne-apoptosis, ukusebenza kwe-caspase-3, ukubonakaliswa kofuzo kanye nobuthi bezidakamizwa kukalwa.Ukuchayeka ku-EPA kanye ne-DHA kwenze i-apoptosis kanye nokwanda kokuzwela ku-bortezomib kumaseli e-MM.Okubalulekile, awazange athinte ukusebenza kwamangqamuzana avamile e-peripheral mononuclear yomuntu.I-Messenger RNA expression array ibonise ukuthi i-EPA ne-DHA iguqule izakhi zofuzo ezihilelekile ezindleleni zokusayina eziningi ezihlanganisa i-nuclear factor (NF) κB, i-Notch, i-Hedgehog, i-oxidative stress kanye ne-Wnt.I-EPA ne-DHA ivimbele umsebenzi we-NFκB futhi yenze i-apo ptosis ngokusebenzisa ukuphazamiseka kwe-mitochondrial nokusebenza kwe-caspase-3.Ucwaningo lwethu luphakamisa ukuthi i-EPA ne-DHA zenza imiphumela ekhethiwe ye-cytotoxic ku-MM futhi ikhulise ukuzwela ku-bortezomib futhi idinga ukuhlola okwengeziwe ekusetshenzisweni okungaba khona kwalawa ma-n-3 polyunsaturated fatty acids ekwelapheni kwe-MM.
