Imikhiqizo

Sekwenziwe ama-metallointercalators asuselwa kuplatinamu (II) ayishumi nanhlanu asebenzisa i-1,10-phenanthroline (phen) ligands esikhundleni, okuhlanganisa i-5-chloro-1,10-phenanthroline (5-Cl-phen), 5-methyl-1,10- i-phenanthroline (5-CH3-phen), 5-amino-1,10-phenanthroline (5-NH2-phen), 5-nitro-1,10-phenanthroline (5-NO2-phen) kanye ne-dipyrido[3,2-d :2',3'-f]quinoxaline (dpq), ne-achiral ethylenediamine (en) kanye ne-chiral ancillary ligands 1S,2S-diaminocyclohexane (S,S-dach) kanye ne-1R,2R-diaminocyclohexane (R,R-dach) .I-cytotoxicity yabo kumugqa weseli ye-L1210 murine leukemia yanqunywa ngokusebenzisa ukuhlolwa kokuvimbela ukukhula.Izakhiwo zensimbi ezine-cytotoxic kakhulu yilezo eziqukethe i-S,S-dach ancillary ligands kanye ne-5-CH3-phen intercalating ligands.I-metallointercalator eyodwa [Pt(5-CH3-phen)(S,S-dach)]Cl2 (5MESS), ibonisa ukwanda kwe-cytotoxicity okuphindwe izikhathi ezingu-5-10 uma kuqhathaniswa nomenzeli womtholampilo i-cisplatin.Kusukela ekuhloleni okubophayo kwe-DNA kubonakala kungekho mehluko obalulekile phakathi kwanoma yiziphi izakhiwo zensimbi, okubonisa ukuthi akukho ukuhlobana okubophayo kwe-DNA noma indlela yokubopha/i-DNA adduct eyakhiwe iyona kuphela eyisinqumo se-cytotoxicity yalo mndeni we-platinum(II)-based. ama-metallointercalators.