Imikhiqizo

Ukwakheka kwe-Acyl-CoA kuqalisa i-cell fatty acid metabolism.I-Acyl-CoAs ikhiqizwa ngokuhlangana kwe-fatty acid ku-Coenzyme A elamula umndeni omkhulu we-acyl-CoA synthetases (ACS).Ngokuphambene, i-acyl-CoAs ingenziwa i-hydrolyzed ngumndeni we-acyl-CoA thioesterases (ACOT).Lapha, sinqume ukulawulwa kokubhalwa phansi kwawo wonke ama-enzyme e-ACS kanye ne-ACOT kuwo wonke amathishu kanye nokuphendula ukuphazamiseka kwe-metabolic.Sithola amaphethini okulawula okudidiyelwe ngaphakathi naphakathi kwale mindeni yezakhi zofuzo kanye nokulawula okuhlukile okwenzeka ngendlela encike kwezicubu kanye neyokuphila.Ngenxa yezinguquko eziphawuliwe ku-ACOT mRNA yochungechunge olude kanye nobuningi bamaprotheni esibindini nasezicubu ze-adipose, sinqume umphumela wokwanda komsebenzi we-cytosolic long-chain thioesterase ku-fatty acid metabolism kulezi zicubu ngokukhiqiza amagundane ashintshashintshayo aveza ngokweqile i-hyperactive mutant ye-Acot7 isibindi noma izicubu ze-adipose.Umsebenzi ophindwe kabili we-cytosolic acyl-CoA thioesterase wehlulekile ukuvikela i-mic e ekukhuluphaleni okubangelwa ukudla, isibindi esinamafutha noma ukumelana ne-insulin, nokho, ukuvezwa ngokweqile kwe-Acot7 kuma-adipocyte kwenza amagundane angabekezeleli amakhaza.Ndawonye, ​​le datha iphakamisa izindlela ezihlukene zokulawula ama-enzyme e-ACS kanye ne-ACOT nokuthi lawa ma-enzyme asebenza ngendlela ehlelekile ukuze alawule umzimba we-fatty acid ngendlela encike kwezicubu.