Imikhiqizo

I-7,8-Dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one iyinhlanganisela enesakhiwo samakhemikhali esiyinkimbinkimbi esithola ukusetshenziswa emikhakheni ehlukahlukene, kuhlanganise namakhemikhali emithi kanye nocwaningo lwe-neuroscience.Okunye okuyinhloko okusebenzisa lokhu i-compound isemkhakheni wekhemikhali yezokwelapha.Isebenza njengebhulokhi yokwakha noma emaphakathi ekuhlanganisweni kwezidakamizwa ezinezinhlelo zokwelapha ezingase zibe khona.I-scaffold ye-benzazepinone ekhona kule nhlanganisela ifana ngokuhlelekile nama-neurotransmitter athile kanye nezinhloso zezidakamizwa, okwenza kube ithuluzi elibalulekile lokuklama nokuthuthukisa izinhlanganisela ezintsha zemithi.Ngokushintsha ukwakheka kwe-7,8-Dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one, osokhemisi bezokwelapha bangakha izinto eziphuma kuzo ezibonisa ukuhlangana okubophayo okukhethekile nokukhetha kuma-receptors ahlukahlukene noma ama-enzyme, okungenzeka aholele ekutholakaleni. yama-novel therapeutic agents.Ngaphezu kwalokho, le nhlanganisela iye yacwaningwa emkhakheni wocwaningo lwe-neuroscience.Isakhiwo se-benzazepinone sifana nama-agonists athile e-dopamine receptor, okuyizinhlanganisela ezenza kusebenze ama-dopamine receptors ebuchosheni.I-Dopamine idlala indima ebalulekile ekulawulweni kwemizwa, ukunyakaza, kanye nezindlela zokuvuza, ikwenze kube okuhloswe ngakho ukwakhiwa kwezidakamizwa ezihlobene nokuphazamiseka kwezinzwa njenge-Parkinson's schizophrenia.Ngokutadisha imiphumela ye-7,8-Dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one kanye nokuphuma kwayo kuma-receptors e-dopamine, ososayensi bangathola ukuqonda ngomsebenzi walezi zokwamukela futhi bathuthukise izindlela zokwelapha ezintsha zemizwa. izimo.Ngaphezu kwalokho, i-7,8-Dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one nayo iye yahlolisiswa ngenxa yemisebenzi yayo engaba namandla e-antioxidant kanye ne-anti-inflammatory.Ingcindezi ye-oxidative kanye nokuvuvukala yizici eziyisisekelo ezimweni ezahlukahlukene ze-pathological, okubandakanya izifo zenhliziyo, ukuphazamiseka kwe-neurodeergenerative, nomdlavuza.Abacwaningi baye baphenya ikhono le-compound lokuqothula ama-radicals mahhala futhi livimbele izinqubo zokuvuvukala, ezingaba nomthelela ekuthuthukisweni kwemithi yokwelapha eqondiswe kulezi zimo. -enye iyinhlanganisela enezicelo eziningi kukhemikhali yezokwelapha kanye nocwaningo lwe-neuroscience.Isakhiwo sayo samakhemikhali esiyingqayizivele siyenza ibe wusizo ekuhlanganiseni abantu abakhetha izidakamizwa, ikakhulukazi labo abaqondise ama-neurotransmitter receptors.Ngaphezu kwalokho, izakhiwo zayo ze-antioxidant kanye ne-anti-inflammatory zivula amathuba okuthuthukisa ukwelashwa kwezifo ezihlukahlukene.Ukuhlola okuqhubekayo kwalesi sithako kanye nokuphuma kwayo kungase kuholele ekutholakaleni okubalulekile nentuthuko emikhakheni yezokwelapha nesayensi yezinzwa.