Imikhiqizo

I-8-Bromo-3-methyl-xanthine, eyaziwa nangokuthi i-8-BMX, iyinhlanganisela yokwenziwa yeqembu lama-xanthines.I-Xanthines iyikilasi lamakhompiyutha afana ne-caffeine ngokwesakhiwo futhi anemiphumela efanayo emzimbeni.Kodwa-ke, i-8-BMX ngokukhethekile ayijwayele ukusetshenziswa noma yaziwa kakhulu uma iqhathaniswa namanye ama-xanthines afana ne-caffeine noma i-theophylline.Okunye ukusetshenziswa okuyinhloko kwe-8-BMX kusekucwaningweni lwesayensi njengomphikisi okhethiwe wama-adenosine receptors.I-Adenosine iyinhlanganisela eyenzeka ngokwemvelo emzimbeni esebenza njenge-neuromodulator futhi idlala indima ezinqubweni ezihlukahlukene zomzimba, kuhlanganise nokulawulwa kokulala, ukuvuvukala, nokusebenza kwenhliziyo.Ngokuvimbela ama-adenosine receptors, i-8-BMX ingakwazi ukushintsha lezi zinqubo futhi inikeze abacwaningi ukuqonda okubalulekile endimeni ye-adenosine ezinhlelweni ezahlukene. uhlelo.Isetshenziswe ocwaningweni lokukhathazeka, ukucindezeleka, kanye nezifo ze-neurodeergenerative ezifana ne-Parkinson kanye ne-Alzheimer's.Ngokuvimbela ama-adenosine receptors, i-8-BMX ingase iguqule ukuhanjiswa kwe-neurotransmission futhi ibe nomthelela wokwelapha kulezi zimo.Kodwa-ke, kufanele kuqashelwe ukuthi ukusetshenziswa kwe-8-BMX kulezi zifundo ikakhulukazi ukuhlolwa futhi akuzange kuhunyushwe ekusetshenzisweni komtholampilo okusabalele.Ngaphandle komthelela wayo ohlelweni lwezinzwa oluphakathi, i-8-BMX nayo isetshenziswe kwezinye izindawo zocwaningo. .Isibonelo, isetshenziswe njengethuluzi lokutadisha indima ye-adenosine receptors emsebenzini we-cardiorespiratory kanye nokuphenya imiphumela ye-adenosine receptor antagonists enhliziyweni nasemaphashini.Ukwengeza, i-8-BMX iye yaphenywa ukuze ikwazi ukulinganisa amandla omzimba okuzivikela kanye nokunciphisa ukuvuvukala.Kubalulekile ukuqaphela ukuthi nakuba i-8-BMX iye yafundelwa ukusetshenziswa kwayo okungenzeka kanye nemiphumela, ukusetshenziswa kwayo okungokoqobo ngaphandle kwezilungiselelo zocwaningo kunomkhawulo.Njengenhlanganisela yokwenziwa, ayitholakali ukuze isetshenziswe ngokujwayelekile noma isetshenziswe.Embonini yezemithi, amanye ama-xanthine afana ne-caffeine noma i-theophylline asetshenziswa kakhulu ngenxa yamaphrofayili awo okuphepha amisiwe kanye nemiphumela eyaziwa kakhulu. ocwaningweni lwesayensi njengomphikisi okhethiwe wama-adenosine receptors.Kuye kwafundelwa imiphumela yayo engaba khona ohlelweni lwezinzwa olumaphakathi, ukusebenza kwenhliziyo nemithambo yegazi, kanye nokuvuvukala.Kodwa-ke, ukusetshenziswa kwayo okungokoqobo ngaphandle kwezilungiselelo zocwaningo kunomkhawulo, futhi amanye ama-xanthines afana ne-caffeine asetshenziswa kabanzi futhi aqashelwa.