I-Albendazole Cas: 54965-21-8
| Inombolo Yekhathalogi | XD91873 |
| Igama Lomkhiqizo | I-Albendazole |
| I-CAS | 54965-21-8 |
| Ifomu le-Molecularla | I-C12H15N3O2S |
| Isisindo samangqamuzana | 265.33 |
| Imininingwane Yesitoreji | 2-8°C |
| Ikhodi Yentela Evumelanisiwe | 29332990 |
Ukucaciswa Komkhiqizo
| Ukubukeka | I-crystalline powder emhlophe |
| U-Asay | 99% iminithi |
| Iphoyinti lokuncibilika | 208-210 °C |
| ukuminyana | 1.2561 (isilinganiso esinzima) |
| inkomba ye-refractive | 1.6740 (isilinganiso) |
| ukuncibilika | Ayincibiliki emanzini, incibilika ngokukhululekile ku-anhydrous formic acid, incibilika kancane ku-methylene chloride, cishe engancibiliki ku-ethanol (amaphesenti angama-96). |
| pka | 10.72±0.10(Okubikezelwe) |
| Ukuncibilika kwamanzi | 0.75mg/L(209 ºC) |
I-Albendazole isidakamizwa esisetshenziselwa ukwelapha izifo ezibangelwa ama-parasites.Inganikezwa ukwelapha isifo sobuchopho esingavamile (i-neurocysticercosis) noma inganikezwa ukwelapha ukutheleleka kwezinambuzane ezibangela isifo sohudo esibalulekile (microsporidiosis).
Okuphuma kubenzimidazole, i-albendazole iyisidakamizwa esine-antihelmintic spectrum ebanzi.Ibonisa umphumela we-antihelmintic ngokumelene ne-cestodes ebucayi kanye ne-nematodes ngokuvimbela inqubo yokuthatha i-glucose ngama-parasites, evezwa ekuqothulweni kwe-glycogen reserves kanye nokunciphisa okulandelayo kwezinga le-adenosintriphophate.Ngenxa yalokho, i-parasite iyayeka ukunyakaza futhi iyafa.Isetshenziselwa ukutheleleka kwe-Acaris lumbricoides, i-Ancylostoma duodenale, i-Necator americanus, i-Enterobius vermicularis, ne-Trichuris trichiura.Amazwi afanayo alo muthi yi-SKF 62979 nezinye.
I-Methyl 5-(propylthio)-2-benzimidazolecarbamate (Eskazole,Zentel) iyi-anthelmintic ebanzi engakamakethwa okwamanje eNyakatho Melika.Itholakala kumkhiqizi ngesisekelo sokusebenzisa ububele.I-Albendazole isetshenziswa kabanzi emhlabeni wonke ekwelapheni ukutheleleka kwe-intestinalnematode.Isebenza ngempumelelo njengokwelashwa ngomthamo owodwa we-ascariasis, izifo ze-hookworm ze-New and Old World, kanye ne-trichuriasis.Ukwelashwa kwemithamo eminingi nge-albendazole caneradicate pinworm, threadworm, capillariasis, clonorchiasis, nesifo se-hydatid.Ukusebenza kahle kwe-albendazole ngokumelene nezikelemu zetape (cestodes) ngokuvamile kuyaguquguquka futhi akukhangisi kangako.
I-Albendazole yenzeka njengempushana emhlophe ecwebezelayo engancibiliki emanzini.Ukumuncwa ngomlomo kwe-albendazoleis kuthuthukiswa ngokudla okunamafutha.Isidakamizwa sidlula ngokushesha futhi sidlule i-first pass metabolism ku-sulfoxide, okuyifomu elisebenzayo ku-plasma.Ukuqedwa kwesigamu sempilo ye-sulfoxide kusuka kumahora ayi-10 kuye kwayi-15.Ukukhishwa okukhulu kwe-biliary kanye nokugaywa kabusha kwe-enterohepatic kwe-albendazolesulfoxide kwenzeka.I-Albendazole ivame ukubekezelelwa kahle ekwelapheni umthamo owodwa we-nematodes yamathumbu.I-highdose, ukwelashwa isikhathi eside okudingekayo ekwelapheni isifo se-clonorchiasis orechinococcal kungaholela emiphumeleni emibi njengokucindezeleka komnkantsha, ukuphakama kwama-enzyme e-hepatic, kanye ne-alopecia.
I-Albendazole inomkhakha obanzi wokusebenza ngokumelene ne-nematodes yamathumbu kanye ne-cestodes, kanye nama-flukes esibindi i-Opisthorchis sinensis, i-Opisthorchis viverrini, ne-Clonorchis sinensis.Iphinde isetshenziswe ngempumelelo ngokumelene ne-Giardia lamblia.I-Albendazole iyindlela yokwelapha ephumelelayo ye-hydatid cyst disease (echinococcosis), ikakhulukazi uma ihambisana ne-praziquantel.Iyasebenza futhi ekwelapheni i-neurocysticercosis yobuchopho nomgogodla, ikakhulukazi uma inikezwa nge-dexamethasone.I-Albendazole iyanconywa ekwelapheni i-gnathostomiasis.
