Imikhiqizo

Ukukhuluphala ngokweqile, uhlobo lwesifo sikashukela sohlobo 2 kanye ne-hyperlipidemia kuvame ukuhlala ndawonye futhi kuhlotshaniswa nokwanda okukhulu kokugula nokufa.Ukusetshenziswa kwe-carbohydrate ecolisisiwe futhi ikakhulukazi i-fructose kuye kwanda kakhulu eminyakeni yamuva nje futhi kuye kwahambisana nokwanda kwezigameko zokukhuluphala nesifo sikashukela.Ucwaningo lwabantu nezilwane luye lwabonisa ukuthi ukudla okuphezulu kwe-fructose kuhlotshaniswa kahle nokwanda kwe-dyslipidemia, ukumelana ne-insulin, kanye nomfutho wegazi ophakeme.I-metabolism ye-fructose yenzeka ngokuyinhloko esibindini futhi i-fructose flux ephezulu iholela ekuqongeleleni okuthuthukisiwe kwe-hepatic triglyceride (i-hepatic steatosis).Lokhu kubangela ukuphazamiseka kwe-glucose kanye ne-lipid metabolism kanye nokukhula kwe-proinflammatory cytokine expression.Lapha sibonisa ukuthi i-fructose ishintsha inkulumo evuselelwe i-glucose ye-acetyl CoA carboxylase (ACC) ecushiwe, i-pSer hormone sensitive lipase (pSerHSL) kanye ne-adipose triglyceride lipase (ATGL) ku-HepG2 ye-hepatic noma i-primary hepatic cell cultures in vitro.Lokhu kwakuhlotshaniswa nokukhuphuka kwe-de novo triglyceride synthesis in vitro kanye ne-hepatic steatosis ku-vivo ku-fructose-versus glucose-fed kanye namagundane adla ukudla okujwayelekile.Lezi zifundo zinikeza ukuqonda okunoveli ezindleleni ezihilelekile ku-fructose-mediated hepatic hypertriglyceridemia futhi zihlonze ukuthatha i-fructose njengendlela entsha yokwelapha engaba khona yezifo ezihlobene ne-lipid.