Imikhiqizo

I-Benzoic acid, i-2-[[1,1-dimethylethoxy)carbonyl]amino]-3-nitro-methyl ester iyinhlanganisela yamakhemikhali engase isetshenziswe emikhakheni ehlukahlukene, kuhlanganise nemithi kanye ne-organic synthesis.Emkhakheni wemithi, le nhlanganisela ingakwazi isebenza njengesandulela noma esimaphakathi sokuhlanganiswa kwama-molecule ahlukahlukene.Isakhiwo salo samakhemikhali esiyingqayizivele, esihlanganisa i-benzoic acid ester ehlanganiswe neqembu le-amino ne-nitro, inikeza amathuba okushintsha okwengeziwe kanye nokuphuma kokunye ukuze kusungulwe imithi emisha.Osokhemisi bezokwelapha bangasebenzisa le nhlanganisela ukwethula ukwehlukahlukana kwesakhiwo kwabaqokelwa izidakamizwa futhi bahlole ubudlelwano be-structure-activity (SAR) ukuze bathuthukise izakhiwo zabo zemithi.Ukusebenza kwe-ester kungenziwa ngokukhetha i-hydrolyzed ukuze kukhiqizwe i-carboxylic acid ehambisanayo, engasebenza njengebhlokhi yokwakha eguquguqukayo ekuthuthukisweni kwezidakamizwa.Amaqembu e-amino kanye ne-nitro, aziwa ngomsebenzi wawo webhayoloji, angakwazi ukusiza ekwakhiweni kwezidakamizwa ezine-antimicrobial, antitumor, noma anti-inflammatory properties.Isakhiwo samakhemikhali samakhemikhali futhi siyenza ifanelekele ukusetshenziswa kwe-organic synthesis.Iqembu le-carboxylate ester lingasebenza njengeqembu elivikelayo lemisebenzi ene-asidi, liyivikele phakathi nokuguqulwa kwamakhemikhali okuhlukahlukene.Amaqembu e-amino ne-nitro angasebenza njengezingxenye ezisebenzayo ukuze kukhishwe okunye okunye noma kuhlanganiswe ukusabela, okuvumela ukuhlanganiswa kwama-molecule ezinto eziphilayo eziyinkimbinkimbi.Ukuguquguquka kwalesi sithako njengento yokuqala noma okuphakathi kuyenza ibe wusizo kosokhemisi bezinto eziphilayo ababambe iqhaza ekuhlanganiseni amakhemikhali amahle, amakhemikhali ezolimo, noma izinto ezikhethekile.Kubalulekile ukuqaphela ukuthi nakuba ukwakheka kwamakhemikhali enhlanganisela kusikisela ukusetshenziswa okungenzeka, ucwaningo olwengeziwe nokuhlola kubalulekile. ngaphambi kokuthi ukusetshenziswa kwayo okuqondile kusungulwe ngokugcwele.Ukuhlola okuphelele, okuhlanganisa ukuhlolwa kwebhayoloji kanye nokuhlolwa kobuthi, kudingeka kwenziwe ukuze kuqondwe iphrofayili yayo yokuphepha futhi kunqunywe ukufaneleka kwayo ekuthuthukisweni kwezidakamizwa.Ukwengeza, amandla ayo okwenziwa kanye nemikhawulo kufanele kuhlolwe ngokusebenzisa izifundo ezibanzi ze-organic synthesis.Kafushane, i-benzoic acid, i-2--[[1,1-dimethylethoxy)carbonyl]amino]-3-nitro-methyl ester inamandla okusetshenziswa emithini yemithi kanye i-organic synthesis.Isakhiwo sayo samakhemikhali esiyingqayizivele sinikeza amathuba okuguqulwa nokuphuma kokunye, okungahlolelwa ukuthuthukiswa kwezidakamizwa noma ukuhlanganiswa kwe-molecule eyinkimbinkimbi.Kodwa-ke, ucwaningo olwengeziwe nokuhlola kuyadingeka ukuze uqonde ngokugcwele ukusetshenziswa kwayo okungase kube khona kanye nemikhawulo kule mikhakha.