Imikhiqizo

I-Benzyl N- [2-(piperidin-4-yl)propan-2-yl]carbamate hydrochloride iyinhlanganisela yamakhemikhali evamise ukusetshenziswa ocwaningweni lwezemithi nasekuthuthukisweni kwezidakamizwa.Isakhiwo sayo samangqamuzana siqukethe iqembu le-benzyl elixhunywe eqenjini elisebenzayo le-carbamate nge-piperidine moiety.Okunye ukusetshenziswa okuyinhloko kwe-Benzyl N-[2-(piperidin-4-yl)propan-2-yl]carbamate hydrochloride injengesandulela. noma okuphakathi ekuhlanganisweni kwenhlanganisela yemithi ehlukahlukene.Ukuba khona kwendandatho ye-piperidine kunikeza le nhlanganisela ngokuguquguquka kokusabela kwamakhemikhali e-organic, okuyenza ibe yinto ebalulekile yokuqala ukuhlanganiswa kwama-molecule ahlukahlukene ayinkimbinkimbi.Ngokwethula le nhlanganisela endleleni yokwenziwa, osokhemisi bangakwazi ukufinyelela uhla olubanzi lwenhlanganisela yenoveli nezinhlelo zokusebenza ezingaba zokwelapha. Ngaphezu kwalokho, i-Benzyl N-[2-(piperidin-4-yl)propan-2-yl]carbamate hydrochloride ingasetshenziswa njenge isisekelo sokwakhiwa kwemithi emisha eqondise izindlela ezithile zebhayoloji noma ama-receptors.Izici zayo zesakhiwo ziyenza ifanelekele ukufakwa kuma-molecule ezidakamizwa, esebenza njenge-pharmacophore noma iqembu eliyisihluthulelo elisebenzayo elibhekele umsebenzi ofunekayo.Ngokulungisa izingxenye ze-benzyl, i-piperidine, noma i-carbamate, abacwaningi bangakwazi ukuthuthukisa amandla esidakamizwa, ukukhetha, kanye nezakhiwo ze-pharmacokinetic.Inhlanganisela ingase futhi isebenze njengethuluzi noma inhlanganisela yereferensi yokutholakala kwezidakamizwa kanye nezifundo zobudlelwane besakhiwo (SAR).Ngokuqhathanisa umsebenzi webhayoloji wokuphuma kokunye okuhlukile noma ama-analogue e-Benzyl N-[2-(piperidin-4-yl)propan-2-yl]carbamate hydrochloride, abacwaningi bangathola imininingwane ngobudlelwano bomsebenzi wesakhiwo, okubavumela ukuthi baklame amandla kakhudlwana. nezinhlanganisela ezikhethiwe.Lolu lwazi lubalulekile ekuthuthukisweni kwezinhlanganisela zomthofu nasekuthuthukisweni kwamakhandidethi asebenza ngempumelelo ezidakamizwa. Ngaphezu kwalokho, i-Benzyl N-[2-(piperidin-4-yl)propan-2-yl]carbamate hydrochloride ingasetshenziswa ocwaningweni lwamakhemikhali emithi. ukufunda indlela yokusebenza kwezidakamizwa ezithile noma ukuphenya i-metabolism yezidakamizwa.Ngokusebenzisa izinguqulo ezilebulwe ngomsakazo noma ezimakiwe zale nhlanganisela, abacwaningi bangakwazi ukulandelela ukusatshalaliswa kwayo kanye nemetabolism ezinhlelweni zebhayoloji.Lolu lwazi lusiza ekuqondeni ukuthi izidakamizwa zicutshungulwa futhi zikhishwe kanjani emzimbeni, okuhlinzeka ngemininingwane ebalulekile ekusebenzisaneni kwezidakamizwa, izinhlobo zemithamo, kanye nokusebenzisana kwezidakamizwa okungaba khona. I-2-yl]carbamate hydrochloride iyinhlanganisela eguquguqukayo esetshenziswa kakhulu ocwaningweni lwezemithi nasekuthuthukisweni kwezidakamizwa.Izici zayo zesakhiwo ziyenza ibe yigugu njengesandulela sokuhlanganiswa kwenhlanganisela yemithi ehlukahlukene futhi njengesakhiwo sokwakhiwa kwemithi emisha.Ngaphezu kwalokho, isebenza njengethuluzi lezifundo ze-SAR, ukutholwa kwezidakamizwa, kanye nocwaningo lwemetabolism.Ukusetshenziswa okuhlukahlukene kwe-Benzyl N-[2-(piperidin-4-yl)propan-2-yl]carbamate hydrochloride kugqamisa ukubaluleka kwayo ekuthuthukisweni kwama-ejenti okwelapha amasha kanye nokuthuthuka kwamakhemikhali okwelapha.