Imikhiqizo

(I-Benzylamine) i-trifluoroboron, eyaziwa nangokuthi i-BnNH2 · BF3, iyi-reagent ebalulekile ekuhlanganiseni kwe-organic kanye ne-catalysis.Kuyinkimbinkimbi eyakhiwe phakathi kwe-benzylamine ne-boron trifluoride (BF3).Nansi incazelo yokusetshenziswa kwayo emagameni angaba ngu-300.Olunye lwezinhlelo zokusebenza eziyinhloko ze-(benzylamine)trifluoroboron sisemkhakheni wokwakhiwa kwebhondi ye-CN.Ingasetshenziswa njenge-catalyst ekuphenduleni okuhlukahlukene kokuxhumanisa, ikakhulukazi ekwakhekeni kwamabhondi e-CN.Lokhu kusabela kubalulekile ekuhlanganisweni kwemithi, amakhemikhali ezolimo, namanye amakhemikhali amahle.I-(benzylamine) trifluoroboron complex isebenza njengesandulela se-intermediate esebenzayo esiza ekuhlanganisweni kwama-nucleophile ne-aryl noma i-alkyl halides, okuvumela ukwakheka kwamabhondi e-carbon-nitrogen.Lokhu kwakheka kwebhondi ye-CN kubalulekile ekwakhiweni kwamangqamuzana ezinto eziphilayo ayinkimbinkimbi anezakhiwo ezifiselekayo nezisebenzayo.Okunye ukusetshenziswa okubalulekile kwe-(benzylamine) trifluoroboron kumkhakha we-peptide kanye ne-protein synthesis.Isetshenziswa njengeqembu elivikelayo lama-amine ku-solid-phase peptide synthesis kanye ne- native chemical ligation.I-(benzylamine)trifluoroboron complex isebenza njengeqembu elivikelayo elisusekayo elingaqhekezeka kalula ngaphansi kwezimo ezithambile.Inikeza ukuvikeleka okuthembekile eqenjini elisebenzayo le-amine ngesikhathi sokukhohlisa kwamakhemikhali okuhlukahlukene ngenkathi ihlala izinzile ngesikhathi sokuhlanganiswa kwe-peptide.Uma ukuhlanganiswa sekuqediwe, iqembu elivikelayo lingasuswa kalula, okuvumela ukukhiqizwa kwezakhiwo ze-peptide zomdabu noma amaprotheni.Ngaphezu kwalokho, (i-benzylamine) i-trifluoroboron ithola ukusetshenziswa emkhakheni we-asymmetric synthesis.Ingaqashwa njenge-organocatalyst ekuguquleni okuhlukahlukene kwe-enantioselective.Ngenxa yemvelo yayo ye-chiral, i-(benzylamine) trifluoroboron complex ingadala i-stereochemistry ngesikhathi sokusabela, okuholela ekwakhekeni kwemikhiqizo ehlanzekile ebonakalayo.Ingasetshenziswa ekuphenduleni okufana nokusabela kwe-aldol asymmetric, ukusabela kwe-Mannich, ama-acylation, nokunye ukusabela kwe-carbon-carbon ne-carbon-nitrogen bond-forming.Izakhiwo ze-organocatalytic ze-(benzylamine) trifluoroboron ziyenza ithuluzi elibalulekile ekuhlanganisweni kwe-chiral intermediate kanye nezithako zemithi esebenzayo.Ngaphezu kwalokho, (i-benzylamine) i-trifluoroboron ingasetshenziswa ekuxhumaneni kwamakhemikhali kanye nesayensi yezinto ezibonakalayo.Ingasebenza njengebhlokhi yokwakha ekuhlanganisweni kwezinhlaka zensimbi-organic (ama-MOF), izakhiwo zokuxhumanisa, nezinye izinto zokusebenza.Ukudidiyelwa kwe-(benzylamine) trifluoroboron nama-ion ensimbi kunikeza ukuzinza nokuqina kulezi zinto zokwenziwa, kube nomthelela ezimpahleni zazo ezingokomzimba, zamakhemikhali, kanye ne-catalytic.Ikhono lokufaka (i-benzylamine) trifluoroboron kulezi zinsiza livula amathuba okwakhiwa nokuthuthukiswa kwezinto ezintsha ngokusetshenziswa kwe-catalysis, ukugcinwa kwegesi, ukuhlukanisa, kanye nokuzwa. i-organic synthesis kanye ne-catalysis.Ukusetshenziswa kwayo ekubunjweni kwebhondi ye-CN, i-peptide kanye ne-protein synthesis, i-asymmetric synthesis, kanye nekhemistry yokuxhumanisa igqamisa ukubaluleka kwayo emikhakheni ehlukahlukene.I-(benzylamine) trifluoroboron complex ihlinzeka ngokusebenza kabusha okuthuthukisiwe nokukhetha, okuvumela ukuhlanganiswa kwama-molecule emvelo ayinkimbinkimbi, izinhlanganisela ze-chiral, nezinto zokusebenza.Izakhiwo zayo ezibalulekile ziyenza ibe ithuluzi elibalulekile labacwaningi abasezikhungweni zemfundo ephakeme nezimboni abasebenzela ukuhlanganiswa kwamakhemikhali amasha, imithi, nezinto zokwakha.