Imikhiqizo

I-Ceramides iwumndeni wama-lipids avela ngokwemvelo asebenza ngokuyinhloko ongqimbeni olungaphezulu lwesikhumba, akhe umgoqo ovikelayo futhi anciphise ukulahlekelwa kwamanzi emvelo e-transepidermal.Amaceramide alungisa ungqimba lwe-stratum corneum ezimweni zesikhumba esomile, athuthukise ukugeleza kwesikhumba, futhi andise umuzwa wokuthamba.Zinenzuzo esikhumbeni esicindezelekile, esibucayi, esinama-scaly, esimahhadla, esomile, esigugile, nesilimele ilanga.Amaceramide adlala indima ebalulekile ekwakhiweni kwezingqimba ze-epidermal ezingaphezulu futhi akha ingxenye ebalulekile yenethiwekhi ye-intercellular membrane.Basiza ukukhiqiza kanye nokugcina umsebenzi wokuvimba isikhumba.Lokhu kubaluleke kakhulu: uma i-hydration ye-stratum corneum igcinwa, khona-ke isebenza ngokujwayelekile mayelana nokuguquguquka nokuguquguquka, ubuqotho bayo buyagcinwa, futhi isikhumba asikwazi ukucasuka.Ukukhiqizwa kwe-ceramide kuncipha ngokukhula, kugcizelela noma yikuphi ukuthambekela esikhumbeni esomile.Uma kuhlanganiswa ekulungiseleleni ukunakekelwa kwesikhumba, ukusetshenziswa kwe-ceramides kwe-topical kungazuzisa i-stratum corneum uma ama-ceramides ekwazi ukugcwalisa izikhala ze-intercellular futhi uma e-hydrolyzed ngama-enzyme angaphandle kwesikhumba alungile esikhumbeni.Ukufakwa okunjalo futhi kungashukumisa ukukhiqizwa kwe-ceramide esikhumbeni, ngaleyo ndlela kwandise okuqukethwe kwe-lipid yemvelo esikhumbeni futhi kuqinise umgoqo wokuvikela wesikhumba, olinganiswa ngokulahleka kwamanzi e-transepidermal.Amaceramide asetshenziswa ngokuphezulu aboniswe ukuthi abamba futhi abophe amanzi, adingekayo ukuze isikhumba sihlale sithambile, sibushelelezi, futhi sinamanzi.amaceramidi emvelo atholakala ezilwaneni nasezitshalweni.Ngenkathi ama-ceramides engenziwa ngokwenziwa, kunzima ukuthola okulingana okufanayo nalawo atholakala emvelweni, okuwenza abe izinto zokusetshenziswa ezibizayo.