Imikhiqizo

I-Cis-1-tert-butyl 3-ethyl 4-aminopyrrolidine-1,3-dicarboxylate hydrochloride iyinhlanganisela yamakhemikhali ethola ukusetshenziswa emkhakheni wamakhemikhali emithi nokuthuthukiswa kwezidakamizwa.Isakhiwo sayo samangqamuzana siqukethe indandatho ye-pyrrolidine eneqembu le-tert-butyl endaweni ye-cis, iqembu le-ethyl, namaqembu amabili e-carboxylate.Le nhlanganisela ngokuvamile itholakala ngendlela yosawoti we-hydrochloride.Okunye ukusetshenziswa okuyinhloko kwe-cis-1-tert-butyl 3-ethyl 4-aminopyrrolidine-1,3-dicarboxylate hydrochloride isekuhlanganiseni nasekuthuthukisweni kwezidakamizwa eziqondise endaweni emaphakathi. isimiso sezinzwa (CNS).Ukuba khona kwendandatho ye-pyrrolidine, kanye namaqembu e-tert-butyl kanye ne-ethyl, kunikeza le nhlanganisela ngezinto ezingase zibe ne-neuroactive.Abacwaningi bangasebenzisa le nhlanganisela njengento yokuqala ukuze bahlanganise ama-analog noma okuphumayo okungase kuhlanganyele ngokukhetha nama-receptors athile noma ama-enzyme ku-CNS.Ngokushintsha ukwakheka nezinto ezibambile, bangakwazi ukuthuthukisa izakhiwo zekhemisi zekhemisi, bathuthukise ukuhlangana kwe-receptor, futhi bathuthukise amandla ayo okwelapha.Ngaphezu kwalokho, i-cis-1-tert-butyl 3-ethyl 4-aminopyrrolidine-1,3-dicarboxylate hydrochloride ingaba kusetshenziswa njengenhlanganisela yethuluzi ezifundweni zebhayoloji ukuze kuphenywe indima yama-receptors athile noma ama-enzyme ezinqubweni zemizwa.Ngokusebenzisa le nhlanganisela njenge-ligand noma i-probe, abacwaningi bangakwazi ukutadisha ukuhlangana okubophayo, ukukhetha, kanye nendlela yokusebenza yalawa ma-receptors noma ama-enzyme.Lolu lwazi lubalulekile ekuqondeni isisekelo samangqamuzana ezinqubo ze-neuropharmacological kanye nasekuthuthukisweni kwezindlela zokwelapha ezinoveli eziqondiswe ezinkingeni ze-neurodegenerative, izimo zengqondo, noma izifo zemizwa.Inhlanganisela iphinde ibe nezinhlelo zokusebenza ezingase zisetshenziswe ekutholweni kwezidakamizwa nasekuhlolweni kokuhlolwa komphumela ophezulu.Ingafakwa emitapweni yolwazi yezinhlanganisela, ezihlolwa ngokumelene nezinhloso ezihlukahlukene, njengama-receptors noma ama-enzyme, ukuze kuhlonzwe izinhlanganisela ezingase zibe khona zokuhola noma abantu abakhetha izidakamizwa.Lokhu kuhlola kuvumela ukuhlonza izinhlanganisela ezibonisa izinto ezifiselekayo zemithi noma imiphumela yokwelapha engaba khona.Ngaphezu kwalokho, i-cis-1-tert-butyl 3-ethyl 4-aminopyrrolidine-1,3-dicarboxylate hydrochloride ingase ithole usizo ekuthuthukisweni kwezidakamizwa.Imikhiqizo ayizinhlanganisela ezingasebenzi noma ezingasebenzi kancane ezidizayinelwe ukuthi zigaywe zibe yisimo sazo esisebenzayo uma sezingaphakathi emzimbeni.Ngokulungisa ukwakheka kwale nhlanganisela, abacwaningi bangakha amafomu e-prodrug azinze kakhudlwana, athuthukise ukutholakala kwe-bioavailability, noma akwazi ukuwela ulwelwesi lwebhayoloji kalula.Lokhu kungathuthukisa izinzuzo zokwelapha zenhlanganisela futhi kuthuthukise izakhiwo zayo ze-pharmacokinetic.Kafushane, i-cis-1-tert-butyl 3-ethyl 4-aminopyrrolidine-1,3-dicarboxylate hydrochloride iyinhlanganisela engase isetshenziswe ekuthuthukisweni kwezidakamizwa ezihlosiwe ku-CNS. , njengenhlanganisela yethuluzi lezifundo zebhayoloji, ekutholweni kwezidakamizwa, nasekuthuthukisweni kwezidakamizwa.Isakhiwo sayo samangqamuzana esiyingqayizivele sinikeza amathuba okuguqulwa kanye nokwenza kahle ukuze kuthuthukiswe izici zayo zemithi kanye nemisebenzi yebhayoloji.Ukuguquguquka kanye namandla ale nhlanganisela kuyenza ibe yimpahla ebalulekile emkhakheni wamakhemikhali okwelapha kanye nokuthuthukiswa kwezidakamizwa.