Imikhiqizo

I-Clopidogrel camphorsulfonate iyinhlanganisela yemithi enefomula yamakhemikhali C16H16ClNO2S·C10H16O4S.Ngokuvamile yaziwa ngokuthi i-Clopidogrel S-oxide camphorsulfonate noma i-Clopidogrel CAMS.Le nhlanganisela iyi-chiral derivative ye-clopidogrel, okuwumuthi we-antiplatelet osetshenziswa kakhulu.Ukusetshenziswa okuyinhloko kwe-Clopidogrel camphorsulfonate kuyisithako esisebenzayo ekwakhiweni kwezidakamizwa ze-antiplatelet.Isebenza ngokuvimbela ukuhlangana kweplatelet, ivimbele ukwakheka kwehlule legazi, nokunciphisa ubungozi bezehlakalo zenhliziyo nemithambo yegazi.I-compound iqondise ngokuqondile i-P2Y12 receptor kuma-platelet, ngaleyo ndlela ivimbele inqubo yokuqalisa futhi ivimbele ukuhlangana kweplatelet.Le ndlela yokusebenza yenza i-Clopidogrel camphorsulfonate iphumelele ekuvimbeleni i-arterial thrombosis kanye nokunciphisa izehlakalo ezimbi zenhliziyo nemithambo yegazi, okuhlanganisa ukuhlasela kwenhliziyo nokushaywa unhlangothi.I-Clopidogrel camphorsulfonate ivamise ukulawulwa ngomlomo ngendlela yamaphilisi noma amaphilisi.Uma isingenile, iqala ukuguqulwa kwe-metabolic esibindini, okuholela ekwakhekeni kwe-metabolite esebenzayo.Le metabolite esebenzayo bese ibophezela ngokungenakuhlehliswa ku-P2Y12 receptor, isebenzisa imiphumela yayo ye-antiplatelet isikhathi eside.Emsebenzini womtholampilo, i-Clopidogrel camphorsulfonate ivame ukunikezwa iziguli ezine-acute coronary syndromes, njenge-angina engazinzile kanye ne-myocardial infarction, noma labo abaye babhekana ne-coronary percutaneous. intervention (PCI) ngokubeka okuqinile.Ibuye isetshenziswe kabanzi ukuvimbela ukuvela kwezenzakalo ze-thrombotic ezigulini ezinomlando we-stroke noma isifo se-peripheral artery.Kubalulekile ukuqaphela ukuthi i-Clopidogrel camphorsulfonate kufanele isetshenziswe kuphela ngaphansi kokuqondisa kochwepheshe bezempilo, ngoba ingase ihlangane neminye imithi noma ibe nokuphikisana kwezinye izidakamizwa. imiphakathi yeziguli.Umthamo kanye nobude besikhathi sokwelashwa kungahluka kuye ngesimo sezempilo somuntu, futhi kungadingeka ukuqapha njalo ukusebenza kweplatelet nokuhlolwa kwegazi ukuze kuqinisekiswe umphumela ophelele wokwelapha. ikakhulukazi labo abathinta i-arterial thrombosis.Izakhiwo zayo ze-antiplatelet kanye nokuvimbela okukhethiwe kwe-P2Y12 receptor kuyenza ibe umuthi ophumelelayo wokunciphisa ingozi yezenzakalo ezimbi zenhliziyo.Kodwa-ke, njenganoma iyiphi inhlanganisela yemithi, ukuqapha kufanele kusetshenziswe ekusetshenzisweni kwayo, futhi iziguli kufanele zihambisane nezincomo kanye nesiqondiso somhlinzeki wazo wezempilo.