Imikhiqizo

I-Cardioprotectant: I-Creatine phosphate iyinto ebalulekile ehlinzeka ngamandla ekufinyezeni kwemisipha kanye ne-metabolism.Iyindawo yokugcina amandla amakhemikhali yemisipha ebushelelezi kanye nemisipha e-striated, futhi isetshenziselwa ukuvuselelwa kwe-ATP.I-Phosphocreatinedisodium yindlela yayo yokwelapha.I-Sodium Creatine Phosphate, igama lekhemikhali i-N-[imino(phosphono)methyl]-N-methylglycine disodium salt, i-ejenti yokuvikela inhliziyo eyasungulwa yi-Italian Ouhui Pharmaceutical Factory ngo-1992. Ifomu le-phosphocreatine lidlala izindima ezibalulekile ezihlukahlukene zomzimba, futhi lisetshenziswa kabanzi ukuvikela i-myocardial ezigulini ezine-ischemia yenhliziyo noma ngesikhathi sokuhlinzwa kwe-Chemicalbook yenhliziyo, kanye nokwelashwa kwezifo zenhliziyo nemithambo yegazi njengokuhluleka kwenhliziyo, i-myocardial infarction kanye ne-arrhythmia.Ingathuthukisa ukusebenza kwenhliziyo nokushintshashintsha kwezinga lenhliziyo ezigulini ezine-ischemic cardiomyopathy.Ngeke nje inikeze amandla amangqamuzana e-myocardial lapho ehlushwa yi-ischemia ne-hypoxia, kodwa futhi ivikele ulwelwesi lwamangqamuzana e-myocardial ekuhlaselweni kwama-radicals angenawo umoya-mpilo nezinye izinto eziyingozi, ezingathinta ukusebenza kwenhliziyo.Ukuvikelwa kwe-myocardial ye-postoperative ezigulini ezinesifo se-valvular engasebenzi kunenzuzo ekubuyiseleni ngemuva kokuhlinzwa komsebenzi wenhliziyo ezigulini ezinesifo se-valvular esingenakukwazi.Ukuwusebenzisa ukwelapha ngokuphelele ukulimala kwe-myocardial ngemva kokuphefumula kwengane esanda kuzalwa kungathuthukisa kakhulu ama-enzyme e-myocardial kanye ne-electrocardiogram, futhi kunomphumela omuhle wokwelapha nokuphepha.

Izici zomsebenzi Lo mkhiqizo uyindawo yokugcina amandla amakhemikhali emisipha yenhliziyo neyohlaka lwamathambo, futhi usetshenziselwa ukuhlanganiswa kabusha kwe-ATP, unikeza amandla enqubo yokufinyela kwe-acomyosin, futhi udlala indima ebalulekile kumetabolism yamandla yokufinyela kwemisipha.Ukunikezwa kwamandla okwanele kuyisici esibalulekile ekwakhekeni nasekuthuthukisweni kokulimala kwe-myocardial cell.

1. Inomphumela obalulekile wokuvikela emsebenzini we-ischemic myocardial systolic, ongabuyisela ngokugcwele ukuqina futhi wehlise ngokushesha umfutho wegazi we-diastolic.

2. Gcina okuqukethwe kwe-adenosine triphosphate ne-creatine phosphate kumaseli, futhi i-Chemicalbook igcina indawo yokugcina amandla e-myocardial.

3. Yehlisa ukulahlekelwa kwe-creatine kinase futhi unciphise umonakalo we-membrane yeseli.

4. Ine-anti-peroxidation properties.

5. Thuthukisa i-microcirculation ye-myocardial.Ngenxa yokuba khona kwamabhondi e-phosphate anamandla aphezulu kuma-molecule e-creatine phosphate, amabhondi e-phosphate enamandla amakhulu angaguqula ngokuqondile i-ADP ibe yi-ATP ngaphansi kwesenzo se-creatine phosphate, futhi anikeze ngokuqondile amandla emzimbeni ukuze usebenze ngokushesha.Njengomkhiqizo omaphakathi we-glycolysis, i-sodium fructose diphosphate idinga ukudlala indima engaqondile ngokusebenzisa i-anaerobic metabolism.

umzila wokwenziwa:

1 Ukusebenzisa i-dibenzyl phosphate njengempahla eluhlaza, sabela nge-oxalyl chloride ukuze uthole i-sebenzyl oxyphosphoryl chloride,

2 Ngaphansi kwesenzo se-triethylamine, i- dibenzyloxyphosphoryl creatine ethyl ester etholwe ukusabela nge-creatine ethyl ester hydrochloride ijikeleziswa ku dibenzyloxyphosphoryl creatinine,

3. Ngemva kwe-palladium carbon catalyzed hydrogenolysis to debenzylate, isabela nge-sodium hydroxide ukuze ithole i-disodium creatinine phosphate,

I-4 i-hydrolyzed kuya ku-1 ngaphansi kwesenzo se-sodium hydroxide.

Ukusetshenziswa: Ilungele ukuvikela i-metabolism ye-myocardial engavamile esimweni se-myocardial ischemia.

Ukusabela okubi, ukuphikisana nemiphumela yezidakamizwa: labo abangezwani nezingxenye zalo mkhiqizo banqatshelwe;labo abanokwehluleka kwezinso okungapheli banqatshelwe ukusebenzisa imithamo emikhulu (5-10g/d).Umjovo osheshayo womjovo ongaphezu kwe-1g ungabangela ukwehla komfutho wegazi.Ukuphathwa kwedosi ephezulu kubangela ukudla okuphezulu kwe-phosphate, okungase kuthinte i-calcium metabolism kanye nokukhiqizwa kwamahomoni alawula i-homeostasis, okuthinta ukusebenza kwezinso kanye ne-purine metabolism.