Imikhiqizo

Amafilimu e-mucoadhesive aqukethe ama-nanoparticles alayishwe i-curcumin athuthukiswa, okuhloswe ngawo ukwandisa isikhathi sokuhlala sefomu lesilinganiso emgodini womlomo kanye nokwandisa ukumuncwa kwezidakamizwa nge-buccal mucosa.Amafilimu alungiswa ngendlela yokukhipha ngemuva kokufakwa kwe-curcumin egcwele i-chitosan-coated polycaprolactone nanoparticles kuzixazululo ze-chitosan ezenziwe ngepulasitiki.Kusetshenziswe inqwaba ye-molar ye-mucoadhesive polysaccharide chitosan kanye nokugxila kwe-plasticizer glycerol ukuze kulungiselelwe izimo zokulungiselela.Amafilimu atholwe kusetshenziswa i-chitosan ye-molar mass ephakathi nendawo ephezulu atholwe efana ne-homogeneous futhi eguquguqukayo.Ama-nanoparticles alayishwe i-Curcumin asatshalaliswa ngokufanayo endaweni yefilimu, njengoba kufakazelwa yi-atomic force microscopy kanye ne-high-resolution field-emission gun scanning electron microscopy (FEG-SEM) izithombe.Ukuhlaziywa kwezigaba zefilimu kusetshenziswa i-FEG-SEM kubonisa ukuba khona kwama-nanoparticles ngaphakathi kwamafilimu.Ngaphezu kwalokho, amafilimu abonise ukuthi anezinga elihle lokugeleza kwamanzi esixazululweni samathe esifanisiwe, abonisa ukuvuvukala okuphezulu okungaba ngu-80% kanye nokulethwa kwe-curcumin okulawulwa isikhathi eside ku-vitro.Le miphumela ibonisa ukuthi amafilimu e-mucoadhesive aqukethe ama-nanoparticles anikeza indlela ethembisayo yokulethwa kwe-buccal ye-curcumin, engase ibe usizo ikakhulukazi ekwelapheni izifo ze-periodontal ezidinga ukulethwa kwezidakamizwa okuqhubekayo.© 2014 Wiley Periodicals, Inc. kanye ne-American Pharmacists Association.