I-Direct Blue Cas: 314-13-6
| Inombolo Yekhathalogi | XD90533 |
| Igama Lomkhiqizo | Okuluhlaza okwesibhakabhaka okuqondile |
| I-CAS | 314-13-6 |
| I-Molecular Formula | I-C34H24N6Na4O14S4 |
| Isisindo samangqamuzana | 960.81 |
| Imininingwane Yesitoreji | I-ambient |
| Ikhodi Yentela Evumelanisiwe | 32129000 |
Ukucaciswa Komkhiqizo
| Ukubukeka | Impushana emnyama |
| Isivivinyo | 99% |
| Ukulahlekelwa Ekumisweni | 10% ubuningi |
| Ukuncibilika emanzini ngo-0.1%. | Sula isixazululo esiluhlaza okwesibhakabhaka |
| Ubude be-wavelengh bokumuncwa okuphezulu | 605 - 613nm |
| I-Specific Absorbance (E1% / 1cm) | 800 min |
I-Vascular hyperpermeability inomthelela ekuguleni kokuvuvukala.Izindlela zamanje zokuhlolwa kwe-vivo kokungena okusekelwe ekwengezeni kwe-albhamuin eboshwe i-Evans Blue (EB) zinzima futhi ngokuvamile azinawo ukuzwela.Sakhe inoveli ye-infrared fluorescence (IRF) methodology yokulinganisa i-EB-albumin extravasation ukuze silinganise ukuvuthwa kwemithambo kumamodeli we-murine.Ukungena kwemithambo okubangelwa i-endotoxaemia kwahlolelwa zonke izitho eziqinile, ubuchopho, isikhumba kanye ne-peritoneum yi-IRF kanye nesilinganiso esivamile esisekelwe ekumunceni kwe-EB ezikhishwe kwezicubu.I-Organ IRF inyuke ngokulandelana ngokugxila okukhulayo kwe-EB ye-intravenous (2.5-25 mg/kg).Izicubu ze-IRF bezizwela kakhulu ekuqongeleleni kwe-EB uma kuqhathaniswa nendlela esekelwe ekumunceni.Ngokufanelekile, umehluko ekungeneni kwemithambo kanye nokunqwabelana kwe-EB yesitho phakathi kwamagundane alashwe i-lipopolysaccharide kanye ne-saline ngokuvamile kwakubalulekile uma kuhlaziywa ukutholwa okusekelwe ku-IRF kodwa hhayi ngokutholwa okusekelwe ekumunceni.I-EB itholwe kuzo zonke izitho ezingu-353 ezihlaziywe nge-IRF kodwa kuphela ku-67% (239/353) wezitho ezihlaziywa ngendlela esekelwe ekumunceni, okubonisa ukuzwela okuthuthukisiwe kokutholwa kwe-EB ezithweni ezine-IRF.Ngokuphambene, i-EB ku-plasma ngemva kokuphathwa kwe-EB yalinganiswa kalula ngazo zombili izindlela ezinokuxhumana okuphezulu phakathi kwezindlela ezimbili (n=116, r2=0.86).Isilinganiso somehluko oqondene nesitho esithile se-EB-IRF ngenxa ye-endotoxin sasilungile lapho i-IRF iqhathaniswa phakathi kwamagundane afaniswa nesisindo, ubulili, nobudala, kanye nezilungiso ezifanele zesisindo sesitho nokugxiliswa kwe-EB plasma.Ngokuphawulekayo, indlela ye-EB-IRF ishiya izitho ziqinile ku-histopathology elandelayo.Kafushane, i-EB-IRF iyinoveli, ezwela kakhulu, esheshayo, futhi indlela elula yokulinganisa okuhlobene kwe-EB ezithweni eziqinile zokwelapha ngokumelene namagundane okulawula.
