Imikhiqizo

I-Ethyl trifluoropyruvate (ETFP) iyinhlanganisela yamakhemikhali ethola ukusetshenziswa ezindaweni ezihlukahlukene, okuhlanganisa i-organic synthesis, ucwaningo lwezemithi, nokuthuthukiswa kwe-agrochemical.Isuselwa ku-pyruvic acid, enama-athomu amathathu e-fluorine (-F) axhunywe kukhabhoni eseduze neqembu le-carboxyl kanye neqembu le-ethyl (-C2H5) elixhunywe ku-carbonyl carbon.Ukusetshenziswa okubalulekile kwe-ETFP kunjengebhulokhi yokwakha eguquguqukayo i-organic synthesis.Iqembu le-trifluoromethyl ku-ETFP liyigugu kakhulu njengoba linikeza izakhiwo zamakhemikhali eziyingqayizivele futhi ezifiselekayo kumakhompiyutha afakwe kuwo.Iqembu le-trifluoromethyl lingathonya ukusebenza kabusha, ukunyibilika, kanye nomsebenzi webhayoloji, okulenze libe yithuluzi elibalulekile losokhemisi bezokwelapha kanye nosokhemisi bezinto eziphilayo zokwenziwa.Ukuba khona kweqembu le-ethyl kuvumela ukuguqulwa okwengeziwe kuma-molecule, okuvumela ukwethulwa kwamaqembu ahlukahlukene asebenzayo futhi kuthuthukise ukuguquguquka okuphelele kwe-compound.I-Etflurane, i-anesthetic evamile yokuhogela, iyisibonelo sohlelo lokusebenza olutholakala ku-ETFP.Ukwenziwa kwe-Etflurane kuhilela ukusabela kwe-ETFP nge-hydrogen fluoride ne-trifluoroacetic acid ukukhiqiza umkhiqizo wokugcina.I-reactivity eyingqayizivele yeqembu le-trifluoromethyl ku-ETFP ivumela ukwethulwa okukhethiwe kwama-athomu e-fluorine ku-molecule ye-Etflurane, inikeze izindawo zayo zokuqeda izinzwa.ETFP iphinde ithole izicelo ekuthuthukisweni kwamakhemikhali e-agrochemicals, ikakhulukazi ama-herbicides kanye nezilawuli zokukhula kwezitshalo.Iqembu le-trifluoromethyl ku-ETFP lingathinta kakhulu umsebenzi webhayoloji walezi zinhlanganisela.Ngokuhlanganisa iqembu le-trifluoromethyl ku-molecule, osokhemisi bangashintsha i-lipophilicity ye-compound, ukuzinza kwe-metabolic, kanye nokubopha okuhlobene ukuze kuqondiswe ama-enzyme noma ama-receptors akhona ezitshalweni.Lokhu kuguqulwa kuvumela ukuklanywa kwemithi yokubulala ukhula esebenza kangcono futhi ekhethiwe engakwazi ukulawula ukukhula kwezitshalo noma ukukhomba ukhula oluthile ngaphandle kokulimaza izitshalo ezifiselekayo. izinhlanganisela ezehlukene zemithi.Iqembu le-trifluoromethyl ku-ETFP lingakwazi ukuthuthukisa izakhiwo ze-pharmacokinetic zomuntu okhethiwe wezidakamizwa, okuholela ekuthuthukisweni kwe-bioavailability, ukuzinza kwe-metabolic, kanye nokubopha okuhlobene nokukhomba amaprotheni.Lokhu kuguqulwa kungathonya amandla omuthi, ukukhetha, kanye namandla okwelapha jikelele.Njengoba nanoma iyiphi inhlanganisela yamakhemikhali, ukuphatha okufanele kanye nezinyathelo zokuphepha kufanele kulandelwe lapho usebenza ne-ETFP.Kubalulekile ukusebenzisa izinto zokuzivikela ezifanele, njengamagilavu ​​nezibuko, futhi usebenze endaweni engenawo umoya.I-ETFP kufanele igcinwe endaweni epholile, eyomile, kude nokushisa namalangabi avulekile.Ekuphetheni, i-ethyl trifluoropyruvate (ETFP) iyinhlanganisela ebalulekile ekuhlanganiseni kwe-organic, ucwaningo lwezemithi, nokuthuthukiswa kwe-agrochemical.Amaqembu ayo e-trifluoromethyl kanye ne-ethyl ayenza ibe yibhulokhi yokwakha eguquguqukayo yokuguqula izakhiwo zamakhemikhali kanye nokuthuthukisa izakhiwo zama-molecule.Kusukela ekuhlanganisweni kwemithi yokubulala izinzwa kuya ekuthuthukisweni kwemithi yokubulala ukhula kanye nemithi, i-ETFP isebenza njengethuluzi elibalulekile losokhemisi ezinhlobonhlobo zezicelo.Ngokuqhubeka nokuhlola ukusebenza kabusha kwayo kanye nezakhiwo, abacwaningi bangavula ukusetshenziswa okusha futhi banikele entuthukweni emikhakheni eyahlukene yesayensi.