I-Cas eluhlaza ngokushesha: 2353-45-9 Impushana ebomvu ukuya ensundu
| Inombolo Yekhathalogi | XD90527 |
| Igama Lomkhiqizo | Okuluhlaza okusheshayo |
| I-CAS | 2353-45-9 |
| I-Molecular Formula | I-C37H34N2Na2O10S3 |
| Isisindo samangqamuzana | 808.85 |
| Imininingwane Yesitoreji | I-ambient |
| Ikhodi Yentela Evumelanisiwe | 32129000 |
Ukucaciswa Komkhiqizo
| Ukubukeka | Impushana ebomvu ukuya ensundu |
| Isivivinyo | ≥99% |
| Indaba engancibiliki emanzini | ≤0.20% |
Ukuvuvukala okungapheli kwe-airway kanye nokulungiswa kabusha, okuhlanganisa i-fibrosis, kuye kwahlongozwa njengengxenye ebalulekile ye-asthma pathophysiology.Ucwaningo lwangaphambilini lwe-airway fibrosis lwenziwe ikakhulukazi ku-asthmatics ethambile futhi emaphakathi ezingeni le-subepithelial "basement membrane" (SBM).Ucwaningo lwamanje lwaklanyelwe ukuhlola ubukhulu be-SBM yomgwaqo omkhulu womoya kanye ne-submucosal collagen deposition, njengoba kulinganiswa ngezindlela ezintathu ezihlukene ze-collagen staining, kuma-endobronchial biopsies kusuka ku-17 eqinile, eyisishiyagalolunye ephakathi, ne-asthmatics ethambile eyisikhombisa, kanye nezifundo eziyisishiyagalombili ezijwayelekile zokulawula.Ama-eosinophil ezicubu kanye nokuguqula i-factor factor-beta (TGF-beta) amasosha omzimba futhi ahlolwe.Kwakungekho mehluko obalulekile ngokwezibalo ubukhulu be-SBM, i-submucosal collagen deposition, izinombolo ze-eosinophil, noma amaseli e-TGF-beta amahle phakathi kwamaqembu amathathu e-asthmatics kanye nezifundo zokulawula ezijwayelekile.Kwaba kuphela lapho kuhlolwa yonke i-asthmatics (n = 33) ndawonye, lapho i-SBM ejiyile ngesizotha (p = 0.04), njengoba ihlolwe yi-collagen yohlobo lwe-III immunostaining, yabonwa uma iqhathaniswa nezifundo zokulawula ezijwayelekile.Naphezu kwalomehluko, akukho mehluko obalulekile owatholakala enanini le-submucosal collagen deposition kanye nenani lama-eosinophil noma amaseli e-TGF-beta aveza amaseli lapho kuqhathaniswa ne-asthmatics ephelele nezihloko zokulawula ezivamile.Ukwengeza, akukho ukuhlobana okubalulekile okutholakele phakathi kokufakwa kwe-collagen nokubala kwe-eosinophil, izinga le-TGF-beta expression, FEV1, noma ubude be-asthma.Le miphumela iphakamisa ukuthi nakuba ukwanda kokufakwa kwe-collagen ku-SBM ezingeni elikhulu lomzila womoya kuyisici sesifuba somoya, kungase kungawuchazi umehluko wokuqina kwesifuba somoya.
