Imikhiqizo

I-Flucytosine, eyaziwa nangokuthi i-5-fluorocytosine noma i-5-FC, imithi yokwenziwa ye-antifungal esetshenziselwa ngokuyinhloko ukwelapha izifo zesikhunta.Ihlukaniswa njenge-antimetabolite, okusho ukuthi iphazamisa izinqubo ezijwayelekile ze-metabolic zamangqamuzana esikhunta, okuholela ekuvinjweni kwawo noma ekufeni.I-Flucytosine ivamise ukulawulwa ngokuhambisana namanye ama-antifungal agents ukuze isebenze kahle.Okunye okubalulekile okusebenzisa i-flucytosine kusekwelapheni izifo zesikhunta ezihlaselayo, ikakhulukazi lezo ezibangelwa uhlobo lwe-Candida ne-Cryptococcus.Ivamise ukusetshenziswa ekuhlanganisweni nenye i-ejenti ye-antifungal, njenge-amphotericin B noma i-fluconazole, ukuze kuthuthukiswe umsebenzi wayo we-antifungal.I-Flucytosine isebenza ngokufaka amangqamuzana okukhunta futhi iguqulelwe ku-5-fluorouracil, i-cytotoxic antimetabolite.I-5-fluorouracil bese iphazamisa ukuhlanganiswa kwesikhunta se-RNA ne-DNA, ngaleyo ndlela ivimbele ukukhula kwesikhunta nokuphindaphinda.Le ndlela yokusebenzisana isiza ukulwa nenqwaba yamagciwane esikhunta futhi yandise ukusebenza kahle kokwelashwa.Okunye ukusetshenziswa okubalulekile kwe-flucytosine kusekwelapheni i-Cryptococcus neoformans meningitis, ukutheleleka okungase kube yingozi empilweni okuthinta ulwelwesi oluzungeze ubuchopho nomgogodla.I-Flucytosine ithathwa njengenye yezindlela zokwelapha zomugqa wokuqala ngokuhlanganiswa ne-amphotericin B yokwelapha lesi simo.Ukwelashwa okuhlangene kusiza ukunqoba imikhawulo yomuthi ngamunye kuphela futhi kuzuze amazinga aphezulu okwelapha.I-Flucytosine ifinyelela emazingeni anele oketshezini lwe-cerebrospinal, ivumela ukuthi iqondise ngempumelelo ukutheleleka kwefungal ohlelweni lwezinzwa oluphakathi.I-Flucytosine ingase isetshenziselwe ukwelashwa kwezinye izifo zesikhunta, njengezifo ezibangelwa izinhlobo ezithile ze-Candida ne-Aspergillus.Kodwa-ke, ukusetshenziswa kwayo kungase kube nomkhawulo ngenxa yengozi yokuthuthukisa ukumelana, njengoba isikhunta singathola izinguquko ezenza kungabi lula ukuthola umuthi.Ukuqapha okuseduze nokuhlolwa ngezikhathi ezithile kwempendulo yokwelapha kubalulekile uma usebenzisa i-flucytosine ukuze kuqinisekiswe imiphumela yokwelashwa efanele.Nakuba i-flucytosine ngokuvamile ibekezelelwa kahle, ingaba nemiphumela ethile emibi.Imiphumela emibi evamile ihlanganisa ukuphazamiseka kwamathumbu, njengokucanuzela kwenhliziyo, ukuhlanza, nesifo sohudo.Kungase futhi kubangele ukucindezelwa komnkantsha, okungase kuphumele ekwehleni kokukhiqizwa kwamangqamuzana egazi.Ukuhlolwa kwegazi okuvamile kuvame ukwenziwa ukuze kuqashwe ukubalwa kwamangqamuzana egazi ngesikhathi sokwelashwa.Kafushane nje, i-flucytosine iyimithi elwa nesikhunta esetshenziswa ekwelapheni okuhlangene zokwelapha izifo zesikhunta, ikakhulukazi lezo ezibangelwa izinhlobo ze-Candida ne-Cryptococcus.Isebenza ngokuphazamisa ukuhlanganiswa kwe-nucleic acid fungal, ivimbela ukukhula nokuphindaphinda kwabo.I-Flucytosine ivame ukusetshenziswa ngokuhlangana namanye ama-antifungal agents futhi ibaluleke kakhulu ekwelapheni i-Cryptococcus neoformans meningitis.Kodwa-ke, ukusetshenziswa kwayo kudinga ukuqapha ngokucophelela ngenxa yengozi yokumelana nemiphumela emibi engase ibe khona.