Imikhiqizo

Ama-guanosine analogues amaningana, okungukuthi i-acyclovir (kanye ne-oral prodrug valaciclovir), i-penciclovir (ngendlela yayo yomlomo, i-famciclovir) kanye ne-ganciclovir, asetshenziswa kabanzi ekwelapheni i-herpesvirus [okungukuthi i-herpes simplex virus type 1 (HSV-1), kanye nohlobo 2 (HSV-2), varicella-zoster virus (VZV) kanye/noma i-human cytomegalovirus (HCMV)] izifo.Eminyakeni yamuva nje, kuye kwasungulwa ama-analogue amasha amaningana e-guanosine, okuhlanganisa okuphuma ku-3-membered cyclopropylmethyl kanye -methenyl (A-5021 kanye ne-synguanol) kanye nokuphuma kwamalungu ayi-6 e-D- kanye ne-L-cyclohexenyl.Umsebenzi we-acyclic/carbocyclic guanosine analogues unqunywe ngokumelene nenqwaba yamagciwane, okuhlanganisa i-HSV-1, HSV-2, VZV, HCMV, kanye nama-herpesviruses omuntu ohlobo 6 (HHV-6), uhlobo 7 (HHV- 7) kanye nohlobo 8 (HHV-8), kanye negciwane le-hepatitis B (HBV).Ama-guanosine analogue amasha (okungukuthi i-A-5021 ne-D- kanye ne-L-cyclohexenyl G) atholwe esebenza ngokukhethekile kulawo magciwane (HSV-1, HSV-2, VZV) afaka ikhodi ye-thymidine kinase (TK), okusikisela ukuthi umsebenzi wabo we-antiviral (okungenani kancane) uncike ku-phosphorylation yi-TK ebangelwa yigciwane.Umsebenzi omakiwe we-antiviral uphinde waqashelwa nge-A-5021 ngokumelene ne-HHV-6 kanye ne-D- ne-L-cyclohexenyl G ngokumelene ne-HCMV ne-HBV.Umsebenzi we-antiviral we-acyclic/carbocyclic nucleoside analogues ungaba namandla ngokuphawulekayo yi-mycophenolic acid, inhibitor enamandla ye-inosine 5'-monophosphate (IMP) dehydrogenase.Ama-analogues amasha e-carbocyclic guanosine (okungukuthi, i-A-5021 kanye ne-D- kanye ne-L-cyclohexenyl G) anesithembiso esikhulu, hhayi nje njengama-antiviral ekwelapheni izifo ze-herpesvirus, kodwa futhi nama-antitumors emithi yokwelapha ehlanganisiwe yofuzo/i-chemotherapy yomdlavuza, inqobo nje uma (ingxenye) yamaseli wesimila edluliselwe isakhi sofuzo segciwane (HSV-1, VZV) TK.