I-Heparin sodium Cas:9041-08-1 emhlophe noma cishe emhlophe, i-hygroscopic powder
| Inombolo Yekhathalogi | XD90184 |
| Igama Lomkhiqizo | I-Heparin sodium |
| I-CAS | 9041-08-1 |
| I-Molecular Formula | I-C12H17NO20S3 |
| Isisindo samangqamuzana | 591.45 |
| Imininingwane Yesitoreji | 2 kuya ku-8 °C |
| Ikhodi Yentela Evumelanisiwe | 30019091 |
Ukucaciswa Komkhiqizo
| Ukubukeka | emhlophe noma ecishe ibe mhlophe, i-hygroscopic powder |
| U-Asay | 99% |
| Ukuzungezisa okuqondile | Izimpahla ezomile akufanele zibe ngaphansi kuka +50° |
| pH | 5.5 - 8.0 |
| I-endotoxin yebhaktheriya | Ngaphansi kuka-0.01 IU ngeyunithi yamazwe ngamazwe ye-heparin |
| I-solvent eyinsalela | Ngokwendlela evamile yangaphakathi enesibalo esiphezulu sendawo, i-methanol, i-ethanol, i-acetone, bese, ngokulandelayo, 0.3%, 0.5%, noma ngaphansi. |
| Izinsalela ekushiseni | 28.0%-41.0% |
| Isodium | 10.5% -13.5% (into eyomisiwe) |
| Amaprotheni | <0.5% (into eyomisiwe) |
| I-nitrogen | 1.3% -2.5% (into eyomisiwe) |
| Ukungcola kwe-Nucleotidic | 260nm<0.10 |
| Insimbi Enzima | ≤ 30ppm |
| Ukucaca nombala wesixazululo | Isixazululo kufanele sicace singenambala;Okufana ne-turbidity, i-ultraviolet-visible spectrophotometry, ukunqunywa kokumunca ku-wavelength engu-640 nm, ngeke ibe ngaphezu kuka-0.018;Okufana nombala, uma kuqhathaniswa nophuzi ojwayelekile we-colorimetric liquid, akufanele ujule |
| Into Ehlobene | Isamba se-dermatan sulfate ne-chondroitin sulphate: hhayi ngaphezu kwenkathi yesiqongo esihambisanayo ku-chomatogram etholwe ngesisombululo sokubhekisela.Noma yikuphi okunye ukungcola: azikho iziqongo ngaphandle kwesiqongo ngenxa ye-determatan sulfate ne-chondroitin sulfate ezitholiwe. |
| anti-FXa/anti-FIIa | 0.9-1.1 |
| I-chromatography ewuketshezi | Isixazululo sesampula sokulawula ku-chromatogram, i-dermatan sulfate (ubude obuphakeme kanye ne-heparin ne-dermatan sulfate) phakathi kwesilinganiso sokuphakama kwesigodi esiphezulu akufanele sibe ngaphansi kuka-1.3, esitholwe ngesixazululo sokuhlola siyefana ngesikhathi sokugcina nokuma esiqongweni esiyinhloko kuchromatogram etholwe nge isisombululo sereferensi.Ukuchezuka okuhlobene nesikhathi sokugcina akufanele kudlule u-5% |
| Isisindo samangqamuzana nokusatshalaliswa kwesisindo samangqamuzana | Isisindo esimaphakathi sesisindo se-molecular kufanele sibe ngu-15000 - 19000. Isisindo samangqamuzana esingaphezu kuka-24000 webanga akufanele sibe ngaphezu kuka-20%, isisindo samangqamuzana angama-8000 - 16000 wesisindo samangqamuzana angu-24000 - 16000 wesilinganiso akufanele sibe ngaphansi. kuno-1 |
| ukulahlekelwa isisindo esomile | ≤ 5.0% |
| Amagciwane amancane | Isibalo se-aerobic esisebenzayo: <10³cfu/g .Isikhunta/yeast <10²cfu/g |
| i-anti-factor IIa | ≥180 IU/mg |
I-Heparin, usawoti we-Sodium iyi-polymer ye-heparin ekhiqiza umphumela wayo omkhulu we-anticoagulant ngokuvula i-antithrombin.Lokhu kuvula kubangela ushintsho lokuvumelana ku-ATIII futhi kuvumela ukuguquguquka okwengeziwe ku-loop yayo yesayithi esebenzayo.I-Heparin iyi-glycosaminoglycan ene-sulfate kakhulu eyaziwa ngokuvimbela amahlule.I-Heparin, i-Sodium Salt nayo iyi-activator ye-RyR ne-ATIII.
Izakhiwo zomzimba nezamakhemikhali: I-Heparin sodium iyimpushana emhlophe noma ecishe ibe mhlophe, ayinaphunga, i-hygroscopic, inyibilika emanzini, ayincibiliki ezincibilikisini eziphilayo njenge-ethanol ne-acetone.Ineshaje eqinile engalungile kusisombululo esinamanzi futhi ingahlangana namanye ama-cations akhe ama-molecular complexes.Izixazululo ezinamanzi zizinze kakhulu ku-pH 7.
I-Anticoagulant: I-Heparin sodium iyi-anticoagulant, i-mucopolysaccharide, usawoti we-sodium we-glucosamine sulfate okhishwa ku-mucosa yamathumbu ezingulube, izinkomo nezimvu, futhi ikhishwa ngamaseli e-mast emzimbeni womuntu.Futhi ngokwemvelo ikhona egazini.I-Heparin sodium inemisebenzi yokuvimbela ukuhlangana kweplatelet nokubhujiswa, ivimbela ukuguqulwa kwe-fibrinogen ibe yi-fibrin monomer, ivimbele ukwakheka kwe-thromboplastin futhi imelane ne-thromboplastin eyakhiwe, ivimbele ukuguqulwa kwe-prothrombin ibe yi-thrombin ne-antithrombin.I-Heparin sodium ingabambezela noma ivimbele ukuhlangana kwegazi kokubili ku-vitro kanye ne-vivo.Indlela yayo yokusebenza iyinkimbinkimbi kakhulu futhi ithinta izixhumanisi eziningi enqubweni ye-coagulation.Imisebenzi yayo yilena: ①ivimbela ukwakheka nokusebenza kwe-thromboplastin, ngaleyo ndlela ivimbele i-prothrombin ekubeni i-thrombin;②Ekugxileni okuphezulu, kunomphumela wokuvimbela i-thrombin nezinye izici zokuhlangana, ukuvimbela i-fibrinogen ekubeni i-fibrin Protein;③ kungavimbela ukuhlanganiswa nokubhujiswa kwama-platelet.Ngaphezu kwalokho, umphumela we-anticoagulant we-heparin sodium usahlobene ne-radical sulfate ekhokhiswa kabi ku-molecule yayo.Izinto ze-alkaline ezishajwe kahle njenge-protamine noma i-toluidine eluhlaza okwesibhakabhaka zinganciphisa ukushajwa kwayo okunegethivu, ngakho-ke ingavimbela ukuqunjelwa kwayo.umphumela.Ngoba i-heparin ingakwazi ukwenza kusebenze futhi ikhulule i-lipoprotein lipase ku-vivo, i-hydrolyze triglyceride kanye ne-low-density lipoprotein yama-chylomicrons, ngakho futhi inomphumela we-hypolipidemic.I-Heparin sodium ingasetshenziswa ekwelapheni isifo se-acute thromboembolic, isatshalaliswa nge-intravascular coagulation (DIC).Eminyakeni yamuva nje, i-heparin itholakale inomphumela wokukhipha i-lipids yegazi.Umjovo we-intravenous noma umjovo ojulile we-intramuscular (noma umjovo ongaphansi kwesikhumba), amayunithi angu-5,000 kuya kwangu-10,000 isikhathi ngasinye.I-Heparin sodium ayinabuthi obuncane futhi ukuthambekela ukopha okuzenzakalelayo kuyingozi ebaluleke kakhulu ye-heparin overdose.Ingasebenzi ngomlomo, kufanele ilawulwe ngomjovo.Umjovo we-intramuscular noma umjovo we-subcutaneous uyacasula kakhulu, ngezinye izikhathi ukungezwani komzimba kungase kwenzeke, futhi ukudlula ngokweqile kungase kubangele ukuboshwa kwenhliziyo;ngezinye izikhathi ukulahlekelwa izinwele zesikhashana kanye nesifo sohudo.Ngaphezu kwalokho, kusengadala ukuphuka okuzenzakalelayo.Ukusetshenziswa isikhathi eside kwesinye isikhathi kungabangela i-thrombosis, okungase kube umphumela wokuncipha kwe-anticoagulase-III.I-Heparin sodium i-contraindicated ezigulini ezinokuthambekela ukopha, ukwehluleka okukhulu kwesibindi kanye nezinso, umfutho wegazi ophakeme, i-hemophilia, ukopha kwe-intracranial, isilonda se-peptic, abesifazane abakhulelwe kanye nangemuva kokubeletha, izimila ze-visceral, ukuhlukumezeka nokuhlinzwa.
Ukusetshenziswa: Ucwaningo lwe-biochemical, olusetshenziselwa ukuvimbela ukuguqulwa kwe-prothrombin ibe yi-thrombin, nomphumela we-antithrombotic.
Ukusetshenziswa: I-Heparin sodium iyisidakamizwa se-mucopolysaccharide biochemical ekhishwe ku-porcine intestinal mucosa enomsebenzi oqinile we-anticoagulant.UMclcan uthole i-femoral mucopolysaccharide heparin esicutshini sesibindi ezinjeni ngenkathi efunda indlela yokujiyisa kwegazi.UBrinkous et al.kwafakazela ukuthi i-heparin inomsebenzi we-anticoagulant.Ngemuva kokuthi i-heparin isetshenziswe njenge-anticoagulant ekusetshenzisweni komtholampilo okokuqala ngqa, ithole ukunakwa okuvela emhlabeni wonke.Nakuba inomlando weminyaka engaphezu kwengu-60 ekusetshenzisweni komtholampilo, awukho umkhiqizo ongawushintsha ngokuphelele kuze kube manje, ngakho-ke kusengenye yezidakamizwa ezibaluleke kakhulu ze-anticoagulant kanye ne-antithrombotic biochemical.Inezinhlobonhlobo zokusetshenziswa kwezokwelapha.Isetshenziselwa ukwelapha i-acute myocardial infarction kanye ne-pathogenic hepatitis.Ingasetshenziswa ngokuhambisana ne-ribonucleic acid ukwandisa ukusebenza kahle kwe-hepatitis B. Ingasetshenziswa kanye nokwelashwa ngamakhemikhali ukuze kuvinjelwe i-thrombosis.Inganciphisa i-lipids yegazi futhi ithuthukise ukusebenza komzimba womuntu.futhi kunomphumela othile.Isisindo esiphansi se-heparin sodium ine-anticoagulant factor Xa umsebenzi.Ucwaningo lwe-Pharmacodynamic lubonise ukuthi isisindo esiphansi samangqamuzana i-heparin sodium inomphumela ovimbela ukwakheka kwe-thrombus kanye ne-arteriovenous thrombosis ku-vivo kanye ne-in vitro, kodwa inomthelela omncane ohlelweni lwe-coagulation kanye ne-fibrinolysis, okuholela kumphumela we-antithrombotic.ukopha mancane amathuba okuba.I-heparin engahlukanisiwe iyinhlanganisela yama-amino glucan glycosides ahlukahlukene angabambezela noma avimbele ukuhlangana kwegazi kokubili ku-vitro kanye ne-vivo.Indlela yayo ye-anticoagulation iyinkimbinkimbi, futhi inomthelela kuzo zonke izici zokuhlangana.Kubandakanya ukuvinjelwa kwe-prothrombin ku-thrombin;ukuvimbela umsebenzi we-thrombin;vimbela ukuguqulwa kwe-fibrinogen ibe yi-fibrin;vimbela ukuqoqwa kweplatelet nokubhujiswa.I-Heparin isengakwazi ukwehlisa i-lipids yegazi, i-LDL ephansi ne-VLDL, ikhulise i-HDL, iguqule i-viscosity yegazi, ivikele amangqamuzana e-vascular endothelial, ivimbele isifo sokuqina kwemithambo yegazi, ikhuthaze ukugeleza kwegazi, futhi ithuthukise ukujikeleza kwegazi.
Ukusetshenziswa: Ucwaningo lwe-biochemical, ukuvimbela ukuguqulwa kwe-prothrombin ibe yi-thrombin.
Ukusetshenziswa: Isetshenziselwa ukubambezeleka nokuvimbela ukujiya kwegazi
