Imikhiqizo

I-7-Hydroxygranisetron iyinhlanganisela esebenza njengomuthi emkhakheni wezokwelapha.Kungokwesigaba sezidakamizwa ezaziwa ngokuthi ama-serotonin 5-HT3 receptor antagonists akhethiwe.Le nhlanganisela iyi-metabolite ye-granisetron, umuthi osetshenziswa kakhulu we-antiemetic.Inhloso eyinhloko ye-7-Hydroxygranisetron ukuvimbela nokwelapha isicanucanu nokuhlanza, ikakhulukazi lezo ezihambisana ne-chemotherapy noma izinqubo zokuhlinza.I-Chemotherapy-induced nausea and vomiting (CINV) iyinkinga enkulu ezigulini ezinomdlavuza ezilashwayo.Le miphumela engemihle ingaba nomthelela omubi kwikhwalithi yempilo yesiguli futhi ingase ibangele ukuphazamiseka kokwelashwa.I-7-Hydroxygranisetron isebenza ngokuvimbela ama-serotonin receptors athile ohlelweni lwezinzwa olumaphakathi, ikakhulukazi lawo asendaweni ye-chemoreceptor trigger zone kanye nesikhungo sokuhlanza.Ngokwenza kanjalo, kusiza ekunciphiseni izimpawu ezibangela ukucanuzela kwenhliziyo nokuhlanza, okuhlinzeka usizo ezigulini.Ngaphezu kokusetshenziswa kwayo kwe-CINV, i-7-Hydroxygranisetron iphinde yabonisa isithembiso ekulawuleni isicanucanu nokuhlanza ngemva kokuhlinzwa (PONV).Ngemuva kwezinqubo zokuhlinzwa, iziguli zivame ukubhekana nokucanuzela kwenhliziyo nokuhlanza ngenxa yemiphumela ye-anesthesia nezinye izici.I-7-Hydroxygranisetron isiza ukuvimbela nokulawula lezi zimpawu, ivumela iziguli ukuba zilulame ngokukhululeka.Uma ilawulwa, i-7-Hydroxygranisetron ivame ukunikezwa ngomthambo noma ngomlomo, kuye ngesimo sesiguli kanye nezidingo zezokwelapha.Umthamo ungahluka ngokusekelwe ezicini ezifana nesisindo somuntu, inqubo ethile noma ukwelashwa, kanye nobukhulu bezimpawu.Kubalulekile ukulandela umthamo onqunyiwe kanye neziqondiso ezinikezwa ochwepheshe bezempilo ukuze kuqinisekiswe ukusebenza kahle futhi ugweme noma yimiphi imiphumela emibi engase ibe khona.Njengemithi eminingi, i-7-Hydroxygranisetron ingaba nemiphumela engemihle engaba khona.Lokhu kungase kuhlanganise ikhanda elibuhlungu, ukuqunjelwa, isifo sohudo, isiyezi, nokukhathala.Ezimweni ezingavamile, abantu bangase babe nokungezwani komzimba noma imiphumela emibi kakhulu.Kubalulekile ukubika noma yiziphi izimpawu eziphathelene nezimpawu noma ukusabela kumhlinzeki wezokunakekelwa kwempilo ukuze kuhlolwe futhi kuphathwe ngendlela efanele.Sengiphetha, i-7-Hydroxygranisetron umuthi osetshenziswa ngokuyinhloko ukuvimbela nokwelapha isicanucanu nokuhlanza okuhambisana nokwelashwa ngamakhemikhali nezinqubo zokuhlinzwa.Ngokuvimbela ama-serotonin receptors athile ohlelweni lwezinzwa olumaphakathi, kusiza ekudambiseni lezi zimpawu ezicindezelayo ezigulini ezinomdlavuza nakubantu abalulama ekuhlinzweni.Nokho, njenganoma yimuphi umuthi, it