I-L-Cystine CAS:56-89-3 99% Amakristalu amhlophe noma i-crystalline powder
| Inombolo Yekhathalogi | XD90322 |
| Igama Lomkhiqizo | I-L-cystine |
| I-CAS | 56-89-3 |
| I-Molecular Formula | I-C6H12N2O4S2 |
| Isisindo samangqamuzana | 240.30 |
| Imininingwane Yesitoreji | I-ambient |
| Ikhodi Yentela Evumelanisiwe | 29309013 |
Ukucaciswa Komkhiqizo
| Ukubukeka | Amakristalu amhlophe noma i-crystalline powder |
| Isivivinyo | 99% |
| Ibanga | I-USP32 |
| Ukuzungezisa okuqondile | -215° kuya ku-225° |
| Izinsimbi ezinzima | <0.0015% |
| AS | 1.5ppm ubuningi |
| I-SO4 | 0.040%ubukhulu |
| Fe | <0.003% |
| Ukulahlekelwa Ekumisweni | 0.20%ubukhulu |
| Insalela ekushiseni | 0.10%ubuningi |
| Cl | 0.10%ubuningi |
Izinhlaka zekristalu ze-carboxypeptidase T (CpT) eziyinkimbinkimbi ezine-phenylalanine ne-arginine substrate analogs - i-benzylsuccinic acid kanye (2-guanidinoethylmercapto) succinic acid - zinqunywe indlela yokubuyisela amangqamuzana ezinqumweni ze-1.57 Å kanye ne-1.62 Å yephrofayili ebanzi ukuze kucaciswe iphrofayili ethile. kwe-enzyme.Izinsalela ze-Conservative Leu211 kanye ne-Leu254 (nakhona kuzo zombili i-carboxypeptidase A ne-carboxypeptidase B) ziboniswe njengezinqumo zesakhiwo zokuqashelwa kwama-hydrophobic substrates, kanti i-Asp263 yayingeyokuqashelwa kwama-substrate ashajwe kahle.Ukuguqulwa kwalezi zinqumo kushintsha iphrofayela ye-substrate: okuhlukile kwe-CpT i-Leu211Gln ithola izici ezifana ne-carboxypeptidase B, kanye nokwehluka kwe-CpT okungu-Asp263Asn ukukhetha okufana ne-carboxypeptidase A.Iluphu ye-Pro248-Asp258 esebenzisana ne-Leu254 ne-Tyr255 iboniswe inesibopho sokubonwa kwezinsalela ze-C-terminal ye-substrate.Ukubophezela kwe-substrate endaweni engaphansi kwe-S1 kuholela ekuguqukeni kwe-ligand-dep yale loop, futhi ukunyakaza kwe-side chain ye-Leu254 kubangela ukuhlelwa kabusha kokuvumelana kwezinsalela ze-Glu277 ezibalulekile ukuze kusetshenziswe i-catalysis.Lokhu ukuqonda kwenoveli ekukhetheni kwe-substrate ye-metallocarboxypeptidase ebonisa ukubaluleka kokusebenzelana phakathi kwesizinda se-S1' kanye nesikhungo se-catalytic.
