Imikhiqizo

I-Ornithine aspartate yayingeyokuqala esetshenziswa emtholampilo ekwelapheni i-hangover kanye ne-hepatic encephalopathy.Ngokuqoqwa kokuhlangenwe nakho kwesicelo somtholampilo, i-ornithine aspartate iye yasetshenziswa kabanzi ekwelapheni izifo zesibindi, futhi izuze imiphumela eqondile yokwelapha ku-hepatic encephalopathy, ukulimala kwesibindi okubangelwa izidakamizwa, isibindi esinamafutha, isifo sokusha kwesibindi kohlobo esingalapheki nezinye izifo. obonwa odokotela.

I-Ornithine aspartate inikeza i-substrate ye-urea ne-glutamine synthesis ku-vivo.I-Glutamine iwumkhiqizo wokukhipha ubuthi be-ammonia, kanye nendlela yokugcina nokuthutha ye-ammonia.Ngaphansi kwezimo ze-physiological and pathological, ukuhlanganiswa kwe-urea kanye nokuhlanganiswa kwe-glutamine kuthinteka yi-ornithine, i-aspartic acid nezinye izinhlanganisela ze-dicarboxyl.I-Ornithine ihileleke cishe kuyo yonke inqubo yokusebenza komjikelezo we-urea kanye nokukhishwa kwe-ammonia.I-arginine yakheka phakathi nale nqubo, bese i-urea ihlukaniswa ukuze yakhe i-ornithine.I-Aspartic acid ibamba iqhaza ekuhlanganiseni kwe-nucleic acid kuma-hepatocytes ukuze kube lula ukulungiswa kwama-hepatocyte awonakele.Ngaphezu kwalokho, ngenxa yokukhuthazwa okungaqondile kwe-aspartic acid enqubweni ye-metabolic yomjikelezo we-tricarboxylic acid kumaseli esibindi, ikhuthaza ukuhlanganiswa kwamandla kumaseli esibindi, okusiza ekulungiseni amangqamuzana esibindi alimele futhi kusheshise ukululama kokusebenza kwesibindi.Inqubekelaphambili yakamuva ibonise ukuthi i-aspartate ingaphinda ivimbele umsebenzi we-inflammasomes ngokusebenzisa i-N-methyl-D-aspartate (NMDA) receptors, ngaleyo ndlela inciphise indlela ye-pharmacological yokusabela kokuvuvukala kwesibindi.I-NMDA receptors iwuhlobo oluncane lwe-ionotropic excitatory glutamate receptors, edlala indima ebalulekile ezinqubweni ze-physiological ezifana nokudluliselwa kwe-synaptic, i-synaptic plasticity, ukufunda kanye nenkumbulo ohlelweni lwezinzwa oluphakathi.Izifundo ze-pathological ezalandela nazo zaqinisekisa ukuthi i-aspartate ithuthukise kakhulu izilonda ezivuvukalayo esibindini.

Isicelo somtholampilo

Emkhakheni wezifo zesibindi: I-Ornithine aspartate isetshenziswa kabanzi njengesidakamizwa esilwa nokuvuvukala kanye ne-hepatoprotective ekwelapheni izifo ezihlukahlukene zesibindi, njenge-hepatic encephalopathy, ukulimala kwesibindi okubangelwa izidakamizwa, isibindi esinamafutha, i-hepatitis engapheli, njll. I-ammonia yegazi ezigulini ezine-encephalopathy kanye nokukhululeka kwezimpawu ze-neuropsychiatric kancane kancane iba umuthi oyinhloko wokwelapha ekwelapheni izifo ezihlukahlukene zesibindi.

I-Ornithine aspartate iyingxenye ebalulekile yokuhlanganiswa kwe-urea ne-glutamine.I-Ornithine ingacupha ama-enzyme abalulekile ohlelweni lwe-urea synthesis - i-ornithine carbamoyltransferase ne-carbamoyl phosphate synthase, futhi ikhuthaze i-ammonia Metabolism ukuze kuzuzwe ukubola kwe-ammonia yegazi, i-aspartic acid njenge-substrate ingakhiqiza i-glutamic acid ne-oxaloacetic acid, i-detoxification yomkhiqizo we-detoxification i-ammonia, futhi iyindawo yokugcina nokuthuthwa kwe-ammonia.I-Oxaloacetate ibamba iqhaza emjikelezweni we-tricarboxylic acid, ikhuthaza ukukhiqizwa kwamandla kumaseli esibindi, futhi yenza amangqamuzana esibindi awonakele ukuba alungiswe, avuselelwe, futhi abuyiselwe ukusebenza kwesibindi.I-Ornithine aspartate ingathuthukisa ngempumelelo ukusebenza kwesibindi, yehlise i-ammonia yegazi, futhi inciphise ngokuhlanganyela i-ammonia nge-lactulose ne-ofloxacin, ngaleyo ndlela ithuthukise kakhulu izinga lokwelapha i-hepatic encephalopathy, okufanele isetshenziswe emtholampilo.

I-Oncology: Ngezinguquko eziqhubekayo ezinhlotsheni nemithamo yemithi yokwelapha ngamakhemikhali, izinkinga ezihlobene nemithi yokwelapha ngamakhemikhali nazo ziyavela, futhi ukulimala kwesibindi kungenye yezinto ezivame kakhulu ukulimala kwesitho.Uma kwenzeka ukulimala kwesibindi, kuzothinta impilo engokomzimba nengqondo yeziguli ngamazinga ahlukahlukene, kuvimbe ukuqaliswa kwemithi yokwelapha ngamakhemikhali, futhi kwenze buthaka umphumela wokwelapha we-chemotherapy.Ezimweni ezimbi kakhulu, ukwehluleka kwesibindi kungase kubeke ukuphila engozini.I-Ornithine aspartate ingathuthukisa kakhulu ukulimala kwesibindi okubangelwa izidakamizwa ze-chemotherapy futhi ithuthukise umphumela wokwelapha weziguli zesimila.

Inkambu yokuhlinza: Ukuhlinzwa kuwukushayisana kwezitho zomzimba wonke wesiguli, futhi ukulimala komsebenzi wesibindi ngemva kokuhlinzwa nakho kuyinkinga evamile.I-Ornithine aspartate ingavimbela futhi yelaphe ukulimala kwesibindi ngemuva kokuhlinzwa futhi ikhuthaze ukululama kweziguli ngemuva kokuhlinzwa.