I-L-Tryptophan Cas: 73-22-3 99% Impuphu emhlophe
| Inombolo Yekhathalogi | XD90295 |
| Igama Lomkhiqizo | I-L-Tryptophan |
| I-CAS | 73-22-3 |
| I-Molecular Formula | I-C11H12N2O2 |
| Isisindo samangqamuzana | 204.22518 |
| Imininingwane Yesitoreji | I-ambient |
| Ikhodi Yentela Evumelanisiwe | 29339980 |
Ukucaciswa Komkhiqizo
| Isivivinyo | 99%imizuzu |
| Ukubukeka | Impushana emhlophe |
| Ibanga | I-USP32 |
| Ukuzungezisa okuqondile | -29.4 ukuze -32.8 |
| pH | 5.5 kuye ku-7.0 |
| Fe | <0.003% |
| Pb | <0.0015% |
| Ukulahlekelwa Ekumisweni | <0.3% |
| Izinsalela ekushiseni | 0.1%ubuningi |
| Cl | 0.05%ubukhulu |
I-Indoleamine 2,3-dioxygenase (IDO1) kanye ne-tryptophan 2,3-dioxygenase (TDO) ama-enzyme amabili ahlukene anesakhiwo esihlukile sokusatshalaliswa kwezicubu kanye nezindima zomzimba, kodwa zombili zigqugquzela ukuguqulwa kwe-tryptophan ku-N-formylkynurenine (NFK).I-IDO1 iqinisekiswe ngokomtholampilo njengethagethi yesidakamizwa esine-molecule encane yomdlavuza, kuyilapho ucwaningo lwangaphambi komtholampilo lubonisa ukuthi i-TDO ingase ibe impokophelo yokwelapha umdlavuza kanye nesifo se-neurodegenerative.Senze ukuhlolwa kokuhlolwa komphumela ophezulu we-IDO1 kanye ne-TDO esekelwe kunoveli yophenyo lwamakhemikhali, i-NFK Green, ethintana ngokuqondile ne-NFK ukuze yakhe i-molecule ye-fluorescent eluhlaza enobude obujabulisayo obungu-400 nm kanye ne-wavelength ekhishwayo engu-510 nm.Sinikeza ukuqhathanisa kokuqala kwezinhlangothi kwenani lezinqamuleli ezishicilelwe ze-IDO1 ne-TDO futhi siveza ukuthi i-preclinical IDO1 inhibitor Compound 5l ibonisa ukusebenza okubalulekile okuphambene ne-TDO, kuyilapho ukukhetha okuhlobene kwamanye ama-inhibitor ashicilelwe kuqinisekisiwe.Ukufaneleka kokuhlolwa kokusebenza okuphezulu kwezivivinyo kuboniswe ngokuhlola umtapo wezincwadi wezinto zamakhemikhali ezingu-87,000 ngefomethi yemithombo engu-384- noma engu-1536.Okokugcina, sibonisa ukuthi ukuhlola kungasetshenziswa futhi ukukala umthamo wamaseli wokugaya i-tryptophan kanye nokukala amandla eselula e-IDO1 ne-TDO inhibitors.
