I-SF Cas eluhlaza okukhanyayo: 5141-20-8 Impushana ensomi ejulile
| Inombolo Yekhathalogi | XD90538 |
| Igama Lomkhiqizo | I-SF eluhlaza ngokukhanyayo |
| I-CAS | 5141-20-8 |
| I-Molecular Formula | C₃₇H₃₄N₂Na₂O₉S₃ |
| Isisindo samangqamuzana | 792.86 |
| Imininingwane Yesitoreji | -15 kuya ku-20 ° C |
| Ikhodi Yentela Evumelanisiwe | 32129000 |
Ukucaciswa Komkhiqizo
| Ukubukeka | Impushana ensomi ejulile |
| Isivivinyo | 99% |
| Ukuncibilika | Incibilika emanzini ukunikeza isisombululo esiluhlaza esicacile |
Ukuhlola ngokuhlelekile izici ezibalayo kanye nokuphepha kodayi abasha abangaba khona ukuze kuhlinzwe intraocular.Odayi abayisithupha bafakiwe ophenyweni: okuluhlaza okukhanyayo SF (LGSF) yellowish, E68, bromophenol blue (BPB), Chicago blue (CB), rhodamine 6G, rhodulinblau -okuyisisekelo 3 (RDB-B3).Wonke amadayi ahlakazwa futhi ahlanjululwe ngesisombululo saline saline esilinganiselwe.Izakhiwo ezimunca ukukhanya zodayi ngamunye zikalwe ekuhlanganiseni okungu-0.05% phakathi kuka-200 no-1000 nm.Izici zokufaka amabala zahlolwa ngokungcolisa izicubu ze-lens capsule kanye nolwelwesi lwe-epiretinal (ERMs), zasuswa ngokuhlinza, ngokugxila kodayi okungu-1.0%, 0.5%, 0.2%, no-0.05%.Amehlo e-porcine e-Enucleated (isikhathi se-postmortem, amahora angu-9) nawo ayenamabala.Ubuthi obuhlobene nodayi buhlolwe ukuhlolwa kwe-colorimetric (MTT) okulinganisa ukuvinjelwa kwe-retinal pigment epithelium (RPE) ukwanda kwamaseli (ARPE-19 kanye namaseli e-RPE ayinhloko yomuntu, iziqephu 3-6).Ukusebenza kweseli kuphinde kwalinganiswa ngokusekelwe ekuhlolweni kokusebenza kwamaseli e-fluorescence enemibala emibili.Odayi baphenywa ekugxilisweni kuka-0.2% no-0.02%.Bonke odayi abaphenywa kulolu cwaningo bagcobe amaphilisi amalensi omuntu, asuswa ngokuhlinza;ama-ERM, ahlutshiwe ngesikhathi sokuhlinzwa kwe-macular pucker;kanye ne-enucleated porcine amehlo, kuye ngokugxila okusetshenzisiwe.Ubukhulu bokumunca ubude begagasi elide lodayi babungaphakathi kwebanga elingu-527 kuya ku-655 nm ekugxilweni kuka-0.05%.I-Rhodamine G6 ne-RDB-B3 ibonise imiphumela emibi ekwandeni kwamaseli e-ARPE-19 ekuhlanganiseni kwe-0.2% futhi yakhishwa ekuphenyweni okuqhubekayo kumaseli e-RPE ayinhloko.Amadayi amane asele awabonisi umthelela onobuthi ku-ARPE-19 kanye nokwanda kwamaseli e-RPE okuyinhloko ekugxilweni kuka-0.2% no-0.02%.Ukusebenza kwamaseli kuthintwa i-LGSF yellowish (0.2%) kanye ne-CB (0.2% kanye no-0.02%).Odayi ababili (E68 kanye ne-BPB) abakhombisanga ubuthi obufanele ku-vitro.Ukuhlolwa okuhlelekile kwamadayi wokusetshenziswa kwe-intraocular kubonakala kuyimpoqo.Kulolu cwaningo odayi abane bahlonzwe abanezici ezisebenzayo zokungcolisa, kanti ababili balaba bodayi abangenawo umthelela onobuthi obonakalayo kumaseli e-RPE ku-vitro.
